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European Journal of Clinical Pharmacology

, Volume 61, Issue 2, pp 161–162 | Cite as

Publication bias in complementary and conventional medicine

  • Alfredo Vannacci
  • Claudia Ravaldi
  • Fiammetta Cosci
Letter to the Editors

Sir,

Ernst and Schmidt [1] recently conducted an interesting and complete review, the first of its kind, aimed at critically evaluating the evidence from randomized clinical trials (RCTs) of homotoxicology, a form of complementary/alternative medicine (CAM) quite popular in Central Europe. Despite mostly positive findings and high ratings on the Jadad score, the authors concluded that the review failed to demonstrate the efficacy of homotoxicology, in that most of the positive results were not based on proper analysis of the data.

The authors particularly emphasized the high level of sponsor bias: in three of the seven RCTs included in the review, at least one author was an employee of the manufacturer; in most articles, no conflicts of interest were declared and many articles were published in a journal closely linked to the manufacturer [1].

Indeed, sponsor bias is one of the most controversial factors that limits the interpretation of RCTs both in CAM and in conventional medicine....

Keywords

Homotoxicology Clinical trials Evidence-based medicine 

References

  1. 1.
    Ernst E, Schmidt K (2004) Homotoxicology—a review of randomised clinical trials. Eur J Clin Pharm 60:299–306CrossRefGoogle Scholar
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    Barbui C, Violante A, Garattini S (2000) Does placebo help establish equivalence in trials of new antidepressants?. Eur Psychiatry 15:268–273Google Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Alfredo Vannacci
    • 1
  • Claudia Ravaldi
    • 2
  • Fiammetta Cosci
    • 2
  1. 1.Department of Preclinical and Clinical PharmacologyUniversity of FlorenceFlorenceItaly
  2. 2.Department of Neurological and Psychiatric Sciences, Psychiatry UnitUniversity of FlorenceFlorenceItaly

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