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TYMS and DPYD polymorphisms in a Turkish population

  • H. S. SüzenEmail author
  • N. Yüce
  • G. Güvenç
  • Y. Duydu
  • T. Erke
Pharmacogenetics

Abstract

Objective:

The thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) enzymes affect the outcome of 5-fluorouracil (5-FU)-based chemotherapy. Genetic polymorphisms of the thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) genes that may affect chemotherapy are described. The aim of this study was to determine the frequencies of TYMS and DPYD polymorphisms in healthy Turkish individuals.

Methods:

Genotyping analyses of the promoter enhancer region of TYMS (TSER) and the exon 14-skipping mutation of the DPYD (DPYD*2A) genes were conducted in 250 unrelated, healthy volunteers from the central region of Turkey using a PCR-based assay.

Results:

The distribution of theTSER*2/*2, *2/*3 and *3/*3 genotypes were 17.6%, 48.8%, and 33.6%, respectively. The frequencies of the TSER*2 and *3 alleles in the Turkish population were 0.42 and 0.58, respectively. No individuals with the variant DPYD*2A allele were identified in the study group.

Conclusion:

The frequency of the TSER*3 allele among members of the Turkish population was similar to frequencies observed in other Caucasian populations but was lower than those found in Japanese and Chinese populations.

Keywords

TYMS DPYD Polymorphism Turkish 

Notes

Acknowledgement

This work was supported by a grant from the Ankara University, Institute of Biotechnology, Project No: 2001-K-120-240.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • H. S. Süzen
    • 1
    Email author
  • N. Yüce
    • 1
  • G. Güvenç
    • 2
  • Y. Duydu
    • 1
  • T. Erke
    • 3
  1. 1.Department of Toxicology, Faculty of PharmacyAnkara UniversityTandoğan, AnkaraTurkey
  2. 2.Institute of BiotechnologyAnkara UniversityBesevler, AnkaraTurkey
  3. 3.Blood Bank and Transfusion CentreBayindir HospitalSöğütözü, AnkaraTurkey

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