Calcified Tissue International

, Volume 64, Issue 2, pp 100–101

Effects of Long-Term Administration of Methotrexate on Bone Mineral Density in Rheumatoid Arthritis

  • L. D.  Carbone
  • G.  Kaeley
  • K. M.  McKown
  • M.  Cremer
  • G.  Palmieri
  • S.  Kaplan

DOI: 10.1007/s002239900585

Cite this article as:
Carbone, L., Kaeley, G., McKown, K. et al. Calcif Tissue Int (1999) 64: 100. doi:10.1007/s002239900585

Abstract.

Because previous studies of high-dose methotrexate usage have demonstrated an effect on bone formation and resorption, this study was done to determine whether long-term, low-dose use of methotrexate for the treatment of rheumatoid arthritis causes bone loss. Bone mineral density (BMD) of the lumbar spine and hip was measured in 10 Caucasian postmenopausal women who had never received methotrexate and 10 Caucasian postmenopausal women who had received the drug for 3 or more years. There were no significant differences in BMD at the lumbar spine (L2–L4) between patients who had used long-term methotrexate compared with patients never treated with methotrexate (1.08 ± 0.08 g/cm2 versus 0.98 ± 0.14 g/cm2, respectively; P= 0.08). Similarly, there were no significant differences in BMD at the femoral neck between methotrexate users and nonusers (0.81 ± 0.08 g/cm2 versus 0.76 ± 0.15 g/cm2, respectively; P= 0.42). These results suggest that long-term low-dose methotrexate treatment for rheumatoid arthritis is not associated with accelerated bone loss.

Key words: Methotrexate — Bone loss — Rheumatoid arthritis. 

Copyright information

© 1999 Springer-Verlag New York Inc.

Authors and Affiliations

  • L. D.  Carbone
    • 1
  • G.  Kaeley
    • 1
  • K. M.  McKown
    • 1
  • M.  Cremer
    • 1
  • G.  Palmieri
    • 1
  • S.  Kaplan
    • 1
  1. 1.University of Tennessee, Memphis, Department of Medicine, Division of Connective Tissue Diseases, Memphis, Tennessee, 38163, USAUS

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