Calcified Tissue International

, Volume 61 , Issue 2 , pp 134 –138 | Cite as

Influence of Body Mass Index on the Age-related Slope of Total and Regional Bone Mineral Content

  • M.  Revilla
  • L. F.  Villa
  • A.  Sánchez-Atrio
  • E. R.  Hernández
  • H.  Rico

Abstract.

The influence of body mass index (BMI) on T scores for total body bone mineral content (TBBMC) and regional bone mineral content (RBMC) was studied in 186 healthy women: 100 postmenopausal, 35 perimenopausal, and 51 premenopausal. The three groups were divided by BMI >25 kg/m2 and BMI <25 kg/m2 and the postmenopausal women were further subdivided by years since menopause (YSM): <10, 10–20, and >20. Tartrate-resistant acid phosphatase (TRAP) concentration was higher in perimenopausal and postmenopausal women with BMI <25 kg/m2 (P < 0.001). T scores for TBBMC and for axial or peripheral RBMC differed (P < 0.05 in all) between women with BMI >25 kg/m2 and BMI <25 kg/m2. The rate of perimenopausal and postmenopausal age-related slope of BMC, as reflected in all measurements, differed with BMI. In the overall group of women, the T score for TBBMC correlated significantly with BMI (r = 0.46, P < 0.0001); this correlation increased when adjusted for age (r = 0.62, P < 0.0001). BMI correlated with TRAP only in postmenopausal women (r = 0.57, P < 0.0001). Yearly TBBMC decline was twice as high in postmenopausal women with BMI <25 kg/m2 (P= 0.0004) than in those with BMI >25 kg/m2; the decline of trunk RBMC was more significant (P < 0.0001). These findings confirm the influence of BMI and gonadal status on bone mass.

Key words: Body mass index — Total and regional bone mineral content — T score — Gonadal status. 

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Copyright information

© 1997 Springer-Verlag New York Inc.

Authors and Affiliations

  • M.  Revilla
    • 1
  • L. F.  Villa
    • 1
  • A.  Sánchez-Atrio
    • 1
  • E. R.  Hernández
    • 1
  • H.  Rico
    • 1
  1. 1.Department of Medicine, University of de Alcalá de Henares, 28801 Madrid, SpainES

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