Calcified Tissue International

, Volume 59, Supplement 1, pp S10–S15 | Cite as

Advances in the noninvasive assessment of bone density, quality, and structure

  • H. K. Genant
  • T. F. Lang
  • K. Engelke
  • T. Fuerst
  • C. -C. Giüer
  • S. Majumdar
  • M. Jergas
Diagnostics: The Correlation Of Bone Mineral Density And Biochemical Markers To Fracture Risk—Where Do We Go From Here?


Recent advances in the development of methods to assess the skeleton noninvasively have contributed to screening for risk of osteoporosis, early detection of the disease, and effective monitoring of its progression and response to therapy. The capability now exists to evaluate the peripheral, central, or entire skeleton as well as the trabecular bone or cortical bone envelopes accurately and precisely, with the capacity to determine bone strength and predict fracture risk. In this article we examine the current and future capabilities of quantitative computed tomography (QCT), quantitative ultrasound (QUS), and magnetic resonance microscopy (µMR) to assess architectural and densitometric properties of the skeleton to enhance the prediction of fracture risk.


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • H. K. Genant
    • 1
  • T. F. Lang
    • 1
  • K. Engelke
    • 1
  • T. Fuerst
    • 1
  • C. -C. Giüer
    • 1
  • S. Majumdar
    • 1
  • M. Jergas
    • 1
  1. 1.Skeletal Section, Radiology DepartmentUniversity of California, San FranciscoSan Francisco

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