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Calcified Tissue International

, Volume 59, Issue 4, pp 231–234 | Cite as

Common Polymorphism of the Vitamin D Receptor Gene is Associated with Variation of Peak Bone Mass in Young Finns

  • A.-M.  Viitanen
  • M.  Kärkkäinen
  • K.  Laitinen
  • C.  Lamberg-Allardt
  • K.  Kainulainen
  • L.  Räsänen
  • J.  Viikari
  • M. J.  Välimäki
  • K.  Kontula

Abstract.

Previous studies suggested a relation between polymorphism of the vitamin D receptor (VDR) gene and bone mineral density (BMD) at perimenopausal age. To enlighten the possible association of the VDR gene polymorphism and BMD, we studied young (20–29 years) adults whose BMD provides a measure of their maximal bone mass. After sequencing the DNA regions flanking the polymorphic BsmI site, we set up a specific solid-phase minisequencing technique to assay this allelic variation. BMD values were adjusted for age, sex, weight, physical activity, smoking, and calcium intake. Young subjects homozygous for the b allele (BsmI site present) had a significantly higher BMD in lumbar spine and femoral neck than those homozygous for the B allele (BsmI site absent). This data shows that the BsmI polymorphism of the VDR gene is associated with peak bone mass. The implication of this result regarding the prevention of osteoporosis deserves further attention.

Key words: Vitamin D receptor — Peak bone mass — Osteoporosis — Solid-phase minisequencing. 

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Copyright information

© Springer-Verlag New York Inc. 1996

Authors and Affiliations

  • A.-M.  Viitanen
    • 1
  • M.  Kärkkäinen
    • 4
  • K.  Laitinen
    • 2
  • C.  Lamberg-Allardt
    • 4
  • K.  Kainulainen
    • 1
  • L.  Räsänen
    • 3
  • J.  Viikari
    • 5
  • M. J.  Välimäki
    • 1
  • K.  Kontula
    • 1
  1. 1.Department of Medicine, University of Helsinki, Central Hospital, FIN-00290 Helsinki, FinlandFI
  2. 2.Research Unit of Alcohol Diseases, University of Helsinki, Central Hospital, FIN-00290 Helsinki, FinlandFI
  3. 3.Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, Helsinki, FinlandFI
  4. 4.Minerva Foundation Institute for Medical Research, Helsinki, FinlandFI
  5. 5.Department of Medicine, University of Turku, Turku, FinlandFI

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