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Association Between the Decline in Muscle Health and the Decline in Bone Health in Older Individuals from the SarcoPhAge Cohort

  • Médéa Locquet
  • Charlotte Beaudart
  • Jean-Yves Reginster
  • Olivier Bruyère
Original Research

Abstract

The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the relationship between bone decline and muscle decline over 1 year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. In this way, this study also highlights the yearly changes in muscle mass (by dual-energy absorptiometry), muscle weakness (by grip strength), and/or physical performance (by the short physical performance battery test). Measurements of areal bone mineral density (aBMD), enabling the diagnosis of osteoporosis, and bone microarchitecture (by means of the trabecular bone score) were also performed each year. A 1-year clinically relevant decline in bone and muscle health components was evidenced using the Edwards–Nunnally index. Among the 232 participants with complete data (75.5 ± 5.4 years, 57.8% women), we observed an association between a clinically relevant decline in the skeletal muscle mass index (SMI) and a decrease in aBMD (adjusted OR = 2.12 [1.14–2.51] for the spine, 2.42 [1.10–5.34] for the hip and 2.12 [1.04–5.81] for the neck), as well as a significant association between SMI and deterioration of the skeletal microarchitecture (aOR = 3.99 [2.07–7.70]). A clinically relevant decline in muscle strength was associated with a decrease in spine aBMD (aOR = 2.93 [1.21–7.12]) and hip aBMD (aOR = 3.42 [1.37–7.64]) only. The decline in muscle performance was related to the decline in bone microarchitecture only (aOR = 2.52 [1.23–5.17]). Individuals with incident sarcopenia had an approximately fivefold higher risk of concomitantly developing osteoporosis. A dynamic relationship between impaired muscle and bone health was observed, with an obvious association between the concomitant incidences of osteoporosis and sarcopenia.

Keywords

Sarcopenia Osteoporosis Follow-up SarcoPhAge study Muscle strength Physical performance 

Notes

Compliance with Ethical Standards

Conflict of interest

Médéa Locquet, Charlotte Beaudart, Jean-Yves Reginster, and Olivier Bruyère declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

The study protocol and related amendments received approval from the competent ethics authority of our institution (under reference 2012/277). All procedures were in accordance with the 1964 Helsinki declaration and its later amendments. Prior to the collection of baseline measurements and at each additional test added, the participants were rigorously informed about the study objectives and procedures, after which they provided informed written consent to the protocol itself and its amendments.

Supplementary material

223_2018_503_MOESM1_ESM.docx (26 kb)
Supplementary material 1 (DOCX 26 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Médéa Locquet
    • 1
  • Charlotte Beaudart
    • 1
  • Jean-Yves Reginster
    • 1
    • 2
  • Olivier Bruyère
    • 1
  1. 1.World Health Organization Collaborating Center for the Public Health Aspects of Musculoskeletal Health and Aging, Department of Public Health Sciences, Epidemiology and Health EconomicsUniversity of LiègeLiègeBelgium
  2. 2.Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of ScienceKing Saud UniversityRiyadhKingdom of Saudi Arabia

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