Calcified Tissue International

, Volume 104, Issue 2, pp 115–129 | Cite as

Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis

  • Wellington Luiz de Oliveira da Rosa
  • Tiago Machado da Silva
  • Arthur Dias Galarça
  • Evandro Piva
  • Adriana Fernandes da SilvaEmail author


The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Statistical analyses were performed by comparing the standardized mean difference of bone formation volume and bone filling percentage (p = 0.05). Ten studies compared the use of rhBMP-2 and iliac crest bone graft (ICBG). The global analysis for bone formation volume and bone filling percentage showed that bioactive materials were similar to ICBG with a standardized mean difference of respectively 0.07 (95% CI − 0.41 to 0.56) and 0.24 (95% CI − 0.32 to 0.80). The available literature suggested that use of rhBMP-2 presented similar bone formation results to those of ICBG in secondary alveolar bone grafting for patients with CLPD.


Bone transplantation Cleft palate Bone morphogenetic protein Review 



This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and DOCFIX #88887.195037/2018-00. The present research was also supported by the Fundação de Amparo à Pesquisa do Rio Grande do Sul (Pronex FAPERGS #16.0471-4) and by National Council of Technological and Scientific Development (CNPq - grant Technological Development).

Author Contributions

WLOR, TMS, and AFS designed the study. WLOR and TMS prepared the first draft of the paper. WLOR was responsible for statistical analysis of the data. WLOR, ADG, and EP prepared the final draft of the manuscript. All authors revised the paper critically for intellectual content and approved the final version. All authors agree to be accountable for the work and to ensure that any questions relating to the accuracy and integrity of the paper are investigated and properly resolved.

Compliance with Ethical Standards

Conflict of interest

Wellington Luiz de Oliveira da Rosa, Tiago Machado da Silva, Arthur Dias Galarça, Evandro Piva, and Adriana Fernandes da Silva have no conflicts of interest related to this work.

Research Involving Human and Animal Participants

There were no human or animal studies conducted by the authors who were described in this review.

Informed consent

The study is with secondary data from other papers. Informed consent was obtained from all individual participants in each included study for whom identifying information is included in this article.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Wellington Luiz de Oliveira da Rosa
    • 1
  • Tiago Machado da Silva
    • 1
  • Arthur Dias Galarça
    • 1
  • Evandro Piva
    • 1
  • Adriana Fernandes da Silva
    • 1
    • 2
    Email author
  1. 1.Department of Restorative Dentistry, School of DentistryFederal University of PelotasPelotasBrazil
  2. 2.Department of Restorative Dentistry, Faculty of DentistryFederal University of PelotasPelotasBrazil

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