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Calcified Tissue International

, Volume 103, Issue 5, pp 512–521 | Cite as

Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis

  • Tim Rolvien
  • Julian Stürznickel
  • Felix N. Schmidt
  • Sebastian Butscheidt
  • Tobias Schmidt
  • Björn Busse
  • Stefan Mundlos
  • Thorsten Schinke
  • Uwe Kornak
  • Michael Amling
  • Ralf Oheim
Original Research

Abstract

Diagnosis and management of adult individuals with low bone mass and increased bone fragility before the age of 50 can be challenging. A number of these patients are diagnosed with mild osteogenesis imperfecta (OI) through detection of COL1A1 or COL1A2 mutations; however, a clinical differentiation from early-onset osteoporosis (EOOP) may be difficult. The purpose of this study was to determine the bone microstructural differences between mild OI and EOOP patients. 29 patients showed mutations in COL1A1 or COL1A2 and were classified as OI. Skeletal assessment included dual-energy X-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and bone turnover serum analyses. Bone microstructure of 21/29 OI patients was assessed and compared to 23 age- and sex-matched patients clinically classified EOOP but without mutations in the known disease genes as well as to 20 healthy controls. In the OI patients, we did not observe an age-dependent decrease in DXA Z-scores. HR-pQCT revealed a significant reduction in volumetric BMD and microstructural parameters in the distal radius and tibia in both the OI and EOOP cohorts compared to the healthy controls. When comparing the bone microstructure of OI patients with the EOOP cohort, significant differences were found in terms of bone geometry in the radius, while no significant changes were detected in all other HR-pQCT parameters at the radius and tibia. Taken together, adult mild OI patients demonstrate a predominantly high bone turnover trabecular bone loss syndrome that shows minor microstructural differences compared to EOOP without mutation detection.

Keywords

Osteogenesis imperfecta HR-pQCT Collagen type I Early-onset osteoporosis Gene panel sequencing 

Notes

Acknowledgements

This project has received funding from the European Community’s Seventh Framework Programme under Grant Agreement No. 602300 (SYBIL) and the German Federal Ministry of Education and Research (BMBF) within the project “Detection and Individualized Management of Early Onset Osteoporosis (DIMEOs).” Felix Schmidt acknowledges a PhD stipend of the Joachim Herz Stiftung in cooperation with the PIER initiative of the University of Hamburg and DESY Hamburg.

Compliance with Ethical Standards

Conflict of interest

Tim Rolvien, Julian Stürznickel, Felix N. Schmidt, Sebastian Butscheidt, Tobias Schmidt, Björn Busse, Stefan Mundlos, Thorsten Schinke, Uwe Kornak, Michael Amling, and Ralf Oheim declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all patients for the retrospective and anonymized database studies.

Supplementary material

223_2018_447_MOESM1_ESM.tiff (1.5 mb)
Supplementary material 1 (TIFF 1581 KB)
223_2018_447_MOESM2_ESM.docx (26 kb)
Supplementary material 2 (DOCX 25 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Tim Rolvien
    • 1
    • 2
  • Julian Stürznickel
    • 1
  • Felix N. Schmidt
    • 1
  • Sebastian Butscheidt
    • 1
  • Tobias Schmidt
    • 1
    • 2
  • Björn Busse
    • 1
  • Stefan Mundlos
    • 3
    • 4
    • 5
  • Thorsten Schinke
    • 1
  • Uwe Kornak
    • 3
    • 4
    • 5
  • Michael Amling
    • 1
  • Ralf Oheim
    • 1
  1. 1.Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Department of OrthopedicsUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Institute of Medical Genetics and Human GeneticsCharité Universitätsmedizin BerlinBerlinGermany
  4. 4.Berlin-Brandenburg School for Regenerative TherapiesCharité-Universitätsmedizin BerlinBerlinGermany
  5. 5.FG Development and DiseaseMax Planck Institute for Molecular GeneticsBerlinGermany

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