Abstract
Hypoparathyroidism is a rare endocrine disorder, but few studies have focused on the epidemiology and hospital management of the disease and none has been performed in Italy. We investigated the prevalence of different forms of hypoparathyroidism among hospitalized patients in Italy during an 8-year period. This study is designed as a retrospective register-based study. We retrieved data from the “Record of Hospital Discharge” (SDO) of the Italian Health Ministry, from the year 2006 to 2013 and analyzed the codes corresponding to hypoparathyroidism-related diagnoses. The inpatient prevalence of the disease was also calculated after excluding repeated hospitalizations. Overall, 27,692 hospitalization episodes for hypoparathyroidism were identified during the entire period (72.2% in women and 27.8% in men; mean age 49.5 ± 22.9 years). The mean length of stay was 7.4 ± 9.8 days (25.9% of the episodes requiring less than 3 days of stay). The mean hospitalization rate for hypoparathyroidism was 5.9/100,000 inhabitants per year and there was a significant decrease during the period of 2006–2013 (p < 0.0001). The mean hospitalization rate for postsurgical hypoparathyroidism was 1.4/100,000 inhabitants per year and the trend showed a significant reduction during the years (p < 0.0001). The mean prevalence of hypoparathyroidism among inpatients was 5.3/100,000 inhabitants per year, and there was a significant decrease over the years (p < 0.0001). Hypoparathyroidism, particularly the postsurgical form of the disease, is not an uncommon condition among hospitalized patients in Italy. We observed a tendency to a decrease in the frequency of hospitalization during the period 2006–2013.
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Acknowledgements
We wish to thank Dr. Flavia Carle and Dr Marco Galadini for their contribution in retrieving data from the Italian Health Ministry database.
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CC contributed to design of the work, acquisition, analysis and interpretation of data, and to drafting the manuscript. JP contributed to acquisition of data and revising the manuscript. FB contributed to acquisition of data. RM contributed to design of the work. PB contributed to acquisition of data. LN contributed to data analysis. LC contributed to design of the work and interpretation of data. MLB contributed to project ideation, design of the work, interpretation of data, and revising the manuscript. SM contributed to project ideation, design of the work, analysis and interpretation of data, and revising the manuscript. All the authors have approved the final version of the manuscript.
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Cristiana Cipriani, Jessica Pepe, Federica Biamonte, Rizieri Manai, Piergianni Biondi, Luciano Nieddu, Luisella Cianferotti, Maria Luisa Brandi and Salvatore Minisola declare that they have no conflict of interest.
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The protocol was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.
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Cipriani, C., Pepe, J., Biamonte, F. et al. The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study. Calcif Tissue Int 100, 278–285 (2017). https://doi.org/10.1007/s00223-016-0222-7
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DOI: https://doi.org/10.1007/s00223-016-0222-7