Calcified Tissue International

, Volume 95, Issue 2, pp 108–111 | Cite as

Prevalence and Risk Factors of Low Bone Mineral Density in Juvenile Onset Ankylosing Spondylitis

  • Jun Bao
  • Yi Chen
  • Yi-Xiao BaoEmail author
Original Research


The objective of this study is to assess the prevalence and risk in patients with juvenile onset ankylosing spondylitis (JoAS) complicated with low bone mineral density (BMD). A total of 112 children and adolescents with JoAS were enrolled in the study. Bone mass was measured from the lumbar spine and the left proximal femur using dual-energy X-ray absorptiometry. According to the 2007 International Society of Clinical Densitometry definitions, a Z score of less than −2 was termed as “low BMD.” Stepwise regression analysis was used to investigate associations between low BMD and disease-related factors including gender, age, weight, height, body mass index, disease duration, HLA-B27 antigen, grades of sacroiliitis, Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), patient global assessment (PGA), spine pain, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Low BMD was found in 18 (16.1 %) cases in at least one of the two measured regions. Lumbar spine BMD had negative correlations with BASDAI, BASFI, spine pain, ESR, and CRP (P < 0.05). Hip BMD significantly negatively correlated with BASDAI and PGA (P < 0.05). In conclusion, patients with JoAS are likely to develop low BMD, which may be related to high disease activity.


Juvenile onset ankylosing spondylitis Osteoporosis Bone mineral density Disease activity 



Areal bone mineral density


Ankylosing spondylitis


Assessment in SpondyloArthritis International Society


Bath Ankylosing Spondylitis Disease Activity Index


Bath Ankylosing Spondylitis Functional Index


Bone mineral density


Body mass index


C-reactive protein


Dual-energy X-ray absorptiometry


Erythrocyte sedimentation rate


International Society of Clinical Densitometry


Juvenile idiopathic arthritis


Juvenile onset ankylosing spondylitis

mNY criteria

Modified New York criteria


Pediatric Position Development Conference


Patient global assessment of disease activity


Standard deviation




Visual analog scale



This study was supported in part by Grants from the National Natural Science Foundation of China (number 81172782).

Human and Animal Rights and Informed Consent

All procedures in the study were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Pediatrics, Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiChina

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