Calcified Tissue International

, Volume 94, Issue 5, pp 469–473 | Cite as

Challenges for the Development of Bone-Forming Agents in Europe

  • John A. KanisEmail author
  • Rene Rizzoli
  • Cyrus Cooper
  • Jean-Yves Reginster
In recent years, significant advances have been made in the management of osteoporosis, particularly with respect to the development of pharmacological interventions to reduce fracture risk. Approved pharmacological interventions in Europe include bisphosphonates, strontium ranelate, raloxifene, bazedoxifene, denosumab, and parathyroid hormone peptides [ 1, 2, 3, 4] (Table  1). Treatments are approved for osteoporosis in postmenopausal women, but alendronate, etidronate, risedronate zoledronic acid, and teriparatide are also approved for the prevention and treatment of glucocorticoid-induced osteoporosis in Europe [ 3], and alendronate, risedronate, zoledronic acid, strontium ranelate, and teriparatide are approved for the treatment of osteoporosis in men.
Table 1

Pharmacological interventions used in the EU for the prevention of osteoporotic fractures [4]


Year of market approval

Dosing regimen

Route of administration



70 mg once weekly or 5 or 10 mg once daily


Bone Mineral Density Zoledronic Acid Teriparatide Denosumab Risedronate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors consulted Amgen (Andreas Grauer), Asahi Kasei Pharma (Koshi Sakamoto, Yasuo Nakamura, Masaya Etoh), Servier (Florence Petit Dop, Yannis Tsouderos), and UCB (John Caminis) to discuss problems in the development of bone-forming agents. The consultees had no part in the writing of this report.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • John A. Kanis
    • 1
    Email author
  • Rene Rizzoli
    • 2
  • Cyrus Cooper
    • 3
    • 4
  • Jean-Yves Reginster
    • 5
  1. 1.Centre for Metabolic Bone Diseases, University of Sheffield Medical SchoolUniversity of SheffieldSheffieldUK
  2. 2.Division of Bone DiseasesGeneva University Hospital and Faculty of MedicineGenevaSwitzerland
  3. 3.MRC Lifecourse Epidemiology UnitUniversity of SouthamptonSouthamptonUK
  4. 4.NIHR Musculoskeletal Biomedical Research UnitUniversity of OxfordOxfordUK
  5. 5.Department of Public Health, Epidemiology and Health EconomicsUniversity of LiègeLiègeBelgium

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