Calcified Tissue International

, Volume 94, Issue 1, pp 98–111

Cells of the Immune System Orchestrate Changes in Bone Cell Function

  • Sarah E. Wythe
  • Vicky Nicolaidou
  • Nicole J. Horwood
Review

DOI: 10.1007/s00223-013-9764-0

Cite this article as:
Wythe, S.E., Nicolaidou, V. & Horwood, N.J. Calcif Tissue Int (2014) 94: 98. doi:10.1007/s00223-013-9764-0

Abstract

There is a complex interplay between the cells of the immune system and bone. Immune cells, such as T and NK cells, are able to enhance osteoclast formation via the production of RANKL. Yet there is increasing evidence to show that during the resolution of inflammation or as a consequence of increased osteoclastogenesis there is an anabolic response via the formation of more osteoblasts. Furthermore, osteoblasts themselves are involved in the control of immune cell function, thus promoting the resolution of inflammation. Hence, the concept of “coupling”—how bone formation is linked to resorption—needs to be more inclusive rather than restricting our focus to osteoblast–osteoclast interactions as in a whole organism these cells are never in isolation. This review will investigate the role of immune cells in normal bone homeostasis and in inflammatory diseases where the balance between resorption and formation is lost.

Keywords

Monocytes Natural killer cells T cells Osteoblast Osteoclast Mesenchymal stem cell 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sarah E. Wythe
    • 1
  • Vicky Nicolaidou
    • 1
  • Nicole J. Horwood
    • 1
  1. 1.Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal SciencesUniversity of OxfordOxfordUK

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