Calcified Tissue International

, Volume 93, Issue 2, pp 101–120 | Cite as

Quality of Life in Sarcopenia and Frailty

  • René Rizzoli
  • Jean-Yves Reginster
  • Jean-François Arnal
  • Ivan Bautmans
  • Charlotte Beaudart
  • Heike Bischoff-Ferrari
  • Emmanuel Biver
  • Steven Boonen
  • Maria-Luisa Brandi
  • Arkadi Chines
  • Cyrus Cooper
  • Sol Epstein
  • Roger A. Fielding
  • Bret Goodpaster
  • John A. Kanis
  • Jean-Marc Kaufman
  • Andrea Laslop
  • Vincenzo Malafarina
  • Leocadio Rodriguez Mañas
  • Bruce H. Mitlak
  • Richard O. Oreffo
  • Jean Petermans
  • Kieran Reid
  • Yves Rolland
  • Avan Aihie Sayer
  • Yannis Tsouderos
  • Marjolein Visser
  • Olivier Bruyère


The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.


Age Aging Muscle weakness Quality of life Malnutrition 



The authors thank Jeremy Grierson, PhD, for his assistance in preparing the draft of the manuscript from the presentations and discussions of the working group participants.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • René Rizzoli
    • 1
  • Jean-Yves Reginster
    • 2
  • Jean-François Arnal
    • 3
  • Ivan Bautmans
    • 4
  • Charlotte Beaudart
    • 2
  • Heike Bischoff-Ferrari
    • 5
  • Emmanuel Biver
    • 1
  • Steven Boonen
    • 6
  • Maria-Luisa Brandi
    • 7
  • Arkadi Chines
    • 8
  • Cyrus Cooper
    • 9
  • Sol Epstein
    • 10
  • Roger A. Fielding
    • 11
  • Bret Goodpaster
    • 12
  • John A. Kanis
    • 13
  • Jean-Marc Kaufman
    • 14
  • Andrea Laslop
    • 15
  • Vincenzo Malafarina
    • 16
  • Leocadio Rodriguez Mañas
    • 17
  • Bruce H. Mitlak
    • 18
  • Richard O. Oreffo
    • 19
  • Jean Petermans
    • 20
  • Kieran Reid
    • 13
  • Yves Rolland
    • 21
  • Avan Aihie Sayer
    • 9
  • Yannis Tsouderos
    • 22
  • Marjolein Visser
    • 23
    • 24
  • Olivier Bruyère
    • 2
  1. 1.Service of Bone DiseasesGeneva University Hospitals and Faculty of MedicineGenevaSwitzerland
  2. 2.Department of Public Health, Epidemiology and Health EconomicsUniversity of LiegeLiegeBelgium
  3. 3.INSERM Research Unit 1048, Faculty of MedicineUniversity of Toulouse and CHU of ToulouseToulouseFrance
  4. 4.Gerontology and Frailty in Ageing Research DepartmentVrije UniversiteitBrusselsBelgium
  5. 5.Centre on Aging and MobilityUniversity of ZurichZurichSwitzerland
  6. 6.Division of Geriatric Medicine & Center for Metabolic Bone Diseases, Department of Internal MedicineLeuven University HospitalLeuvenBelgium
  7. 7.Department of Internal MedicineUniversity of FlorenceFlorenceItaly
  8. 8.Amgen Inc.Thousand OaksUSA
  9. 9.MRC Lifecourse Epidemiology UnitUniversity of SouthamptonSouthamptonUK
  10. 10.Division of EndocrinologyMount Sinai School of MedicineNew YorkUSA
  11. 11.Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on AgingTufts UniversityBostonUSA
  12. 12.Department of MedicineUniversity of PittsburghPittsburghUSA
  13. 13.WHO Collaborating Centre for Metabolic Bone DiseasesUniversity of SheffieldSheffieldUK
  14. 14.Department of EndocrinologyGhent University HospitalGentBelgium
  15. 15.Austrian Agency for Health and Food SafetyViennaAustria
  16. 16.Department of GeriatricsHospital San Juan de DiosPamplonaSpain
  17. 17.Department of GeriatricsUniversity Hospital of GetafeMadridSpain
  18. 18.Lilly Research LaboratoriesEli Lilly and CompanyIndianapolisUSA
  19. 19.Bone and Joint Research Group, Institute of Developmental SciencesUniversity of Southampton Medical SchoolSouthamptonUK
  20. 20.Service of GeriatricsCHU of LiegeLiegeBelgium
  21. 21.Gérontopôle of ToulouseUniversity of Toulouse III, CHU PurpanToulouseFrance
  22. 22.Institut de Recherches Internationales ServierSuresnesFrance
  23. 23.Department of Health SciencesVU UniversityAmsterdamThe Netherlands
  24. 24.Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care ResearchVU University Medical CenterAmsterdamThe Netherlands

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