Calcified Tissue International

, 85:507

Molecular Variation in Neuropeptide Y and Bone Mineral Density Among Men of African Ancestry

  • Louis J. Goodrich
  • Laura M. Yerges-Armstrong
  • Iva Miljkovic
  • Cara S. Nestlerode
  • Allison L. Kuipers
  • Clareann H. Bunker
  • Alan L. Patrick
  • Victor W. Wheeler
  • Joseph M. Zmuda
Article

DOI: 10.1007/s00223-009-9307-x

Cite this article as:
Goodrich, L.J., Yerges-Armstrong, L.M., Miljkovic, I. et al. Calcif Tissue Int (2009) 85: 507. doi:10.1007/s00223-009-9307-x

Abstract

Neuropeptide Y (NPY) is a physiological candidate gene for the regulation of body weight and has more recently been implicated in regulating bone mass. The current study sought to test if inherited variation in NPY might influence BMD in a population of African-ancestry men who have high bone mineral density (BMD). We genotyped 17 tagging single-nucleotide polymorphisms (SNPs) across the NPY gene region in 1,113 randomly selected men of African ancestry aged ≥40 years and tested for association with anthropometric characteristics and proximal femur BMD. The homozygous rare genotype of four SNPs was associated with a 0.92–1.59% decrease in stature (corrected P < 0.05). No SNP was associated with body mass index or body weight. Two SNPs in a 5-kb linkage disequilibrium block encompassing exons 3 and 4 were associated with proximal femur BMD, adjusted for age, body weight, and height (corrected P < 0.05). These results suggest that genetic variation at the NPY locus may contribute to bone density, independently of body weight.

Keywords

Neuropeptide Y Bone mineral density African Polymorphism Men 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Louis J. Goodrich
    • 1
  • Laura M. Yerges-Armstrong
    • 1
  • Iva Miljkovic
    • 1
  • Cara S. Nestlerode
    • 1
  • Allison L. Kuipers
    • 1
  • Clareann H. Bunker
    • 1
  • Alan L. Patrick
    • 2
  • Victor W. Wheeler
    • 2
  • Joseph M. Zmuda
    • 1
    • 3
  1. 1.Department of Epidemiology, Graduate School of Public HealthUniversity of PittsburghPittsburghUSA
  2. 2.The Tobago Health Studies OfficeScarborough, TobagoTrinidad and Tobago
  3. 3.Department of Human Genetics, Graduate School of Public HealthUniversity of PittsburghPittsburghUSA

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