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Assessment of Clinical Risk Factors to Validate the Probability of Osteoporosis and Subsequent Fractures in Korean Women

  • Yoo Mee Kim
  • Noo-Rie Hyun
  • Ho-Sang Shon
  • Hae-Soon Kim
  • So-Young Park
  • Il-Hyung Park
  • Yoon-Sok Chung
  • Hong-Geun Jung
  • Do-Hee Kim
  • Sung-Kil LimEmail author
Article

Abstract

This cross-sectional, observational study was designed to identify clinical risk factors of osteoporosis and fractures in Korean women to validate the probability of osteoporosis and subsequent fractures. A total of 1541 Korean women were recruited nationally. Fracture history of any site, risk factors of osteoporosis, and fall-related risk factors were surveyed and physical performance tests were conducted. Peripheral dual-energy X-ray absorptiometry was used to measure calcaneus bone mineral density (BMD). The number of positive responses on the modified 1-min osteoporosis risk test was related to the risk of osteoporosis. The frequency of osteoporosis was higher in those with a height reduction of >4 cm and a reduced body mass index (BMI). Multivariate analysis showed that older age and lower BMI were related to higher relative risk of osteoporosis. Time required to stand up from a chair and questions related to fall injury were significantly related to clinical fracture history of any site. Multivariate analysis showed that the relative risk of fractures at any site was higher in older subjects with a lower T-score and parental hip fracture history. This study shows that age and BMI are the most significant clinical risk factors for osteoporosis and that age, BMD, and parental history of hip fracture are highly applicable risk factors for validating the probability of osteoporotic fractures in Korean women.

Keywords

Bone mineral density Falls Fractures Osteoporosis Risk assessment 

Notes

Acknowledgments

The authors thank the co-investigators and those who participated voluntarily in the free osteoporosis examination campaign. The co-investigators were: Hye Jung Kim, M.D., Wonkwang University Hospital; Yeun Sun Kim, M.D., Gachon University Gil Medical Center; Soon Hee Lee, M.D., Inje University Pusan Paik Hospital; Ji Hyun Park, M.D., Chonbuk National University Hospital; Yumie Rhee, M.D., Yonsei University College of Medicine; and Young Jun Won, M.D., Kwandong University Myongji Hospital. This study was supported by sanofi-aventis Korea Co., Ltd. All authors had access to all of the data used in this analysis.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Yoo Mee Kim
    • 1
    • 2
  • Noo-Rie Hyun
    • 3
  • Ho-Sang Shon
    • 4
  • Hae-Soon Kim
    • 5
  • So-Young Park
    • 6
  • Il-Hyung Park
    • 7
  • Yoon-Sok Chung
    • 8
  • Hong-Geun Jung
    • 9
  • Do-Hee Kim
    • 10
  • Sung-Kil Lim
    • 2
    • 11
    • 12
    Email author
  1. 1.Division of Endocrinology, Department of Internal MedicineNHIC Ilsan HospitalGoyangSouth Korea
  2. 2.Division of Endocrinology, Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea
  3. 3.Sanofi-Aventis KoreaSeoulSouth Korea
  4. 4.Division of Endocrinology, Department of Internal MedicineCatholic University of Daegu School of MedicineDaeguSouth Korea
  5. 5.Division of Endocrinology, Department of Internal MedicineKeimyung University Dongsan Medical CenterDaeguSouth Korea
  6. 6.Division of Endocrinology, Department of Internal Medicine Cheil General Hospital, Kwandong University College of MedicineSeoulSouth Korea
  7. 7.Department of Orthopaedic SurgeryKyungpook National University HospitalDaeguSouth Korea
  8. 8.Division of Endocrinology, Department of Internal MedicineAjou University School of MedicineSuwonSouth Korea
  9. 9.Department of Orthopaedic SurgeryKonkuk University HospitalSeoulSouth Korea
  10. 10.Division of Endocrinology, Department of Internal MedicineDankook University HospitalSeoulSouth Korea
  11. 11.BK21 Project for Medical ScienceYonsei University College of MedicineSeoulSouth Korea
  12. 12.Institute of Endocrine ResearchYonsei University College of MedicineSeoulSouth Korea

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