Calcified Tissue International

, Volume 73, Issue 5, pp 463–469 | Cite as

Bone Mineral Density and Lifetime Physical Activity in South African Women

  • L. Micklesfield
  • L. Rosenberg
  • D. Cooper
  • M. Hoffman
  • A. Kalla
  • I. Stander
  • E. Lambert
Clinical Investigations

Abstract

We investigated the relation between lifetime physical activity and bone mineral density (BMD) in South African women using data collected in a case-control study of breast cancer in relation to BMD. Subjects (n = 144) were of black African or mixed ancestral origin, and <60 years of age (mean age 42.6 ± 8.9 years). Cases had newly diagnosed breast cancer (n = 62) and controls were referred for conditions unrelated to BMD or breast cancer (n = 82). Physical activity data consisting of household, occupational and leisure-time activity, and activity for transport, were collected via questionnaire at 4 life stages (epochs), viz. 14–21, 22–34, 35–50, and 50+ years of age. Total energy (MET hrs) and peak strain scores were calculated. Lumbar spine and total proximal femur BMD were measured using dual-energy x-ray absorptiometry. BMD measures were similar between groups, therefore data were combined. BMD measures were unrelated to total lifetime physical activity. However, the major determinants of total proximal femur BMD included age, transport activity including walking and bicycling between the ages of 14 and 21 years, and current weight (adjusted r2 = 0.33, P < 0.0001). The major determinants of lumbar spine BMD included age, household energy expenditure between the ages of 14 and 21 years, and current weight (adjusted r2 = 0.23, P < 0.0001). Total peak bone strain score for activities between 14–21 years of age was also significantly correlated with lumbar spine BMD (r = 0.18, P < 0.05). Intraclass correlation coefficients to assess tracking of activity through epochs 1, 2, and 3 were high for total energy expenditure (0.96; 95%CI: 0.94–0.97), household (0.98; 95%CI: 0.97–0.99) and occupational activity (0.78; 95%CI: 0.71–0.84) and activity for transport (0.92; 95%CI: 0.89–0.94). These data suggest that walking or activities resulting in impact loading at a young age are associated with higher BMD in later years. In addition, our findings suggest tracking of physical activity over time.

Keywords

Bone density Physical activity Questionnaire Women Walking 

Notes

Acknowledgements

The data collection for this study was supported by grant R01CA60954 from the U.S. National Cancer Institute.

References

  1. 1.
    Suleiman, S, Nelson, M, Li, F, Buxton-Thomas, M, Moniz, C 1997Effect of calcium intake and physical activity level on bone mass and turnover in healthy, white, postmenopausal women.Am J Clin Nutr66937943PubMedGoogle Scholar
  2. 2.
    Aloia, JF, Vaswani, AN, Yeh, JK, Cohn, SH 1988Premenopausal bone mass is related to physical activity.Arch Intern Med148121123CrossRefPubMedGoogle Scholar
  3. 3.
    Kanders, B, Dempster, DW, Lindsay, R 1988Interaction of calcium nutrition and physical activity on bone mass in young women.J Bone Miner Res3145149PubMedGoogle Scholar
  4. 4.
    Brewer, V, Meyer, BM, Keele, MS, Upton, SJ, Hagan, RD 1983Role of exercise in prevention of involutional bone loss.Med Sci Sports Exerc15445449PubMedGoogle Scholar
  5. 5.
    Khan, KM, Bennell, KL, Hopper, JL, Flicker, L, Nowson, CA, Sherwin, AJ, Crichton, KJ, Harcourt, PR, Wark, JD 1998Self-reported ballet classes undertaken at age 10-12 years and hip bone mineral density in later life.Osteoporos Int8165173PubMedGoogle Scholar
  6. 6.
    Damilakis, J, Perisinakis, K, Kontakis, G, Vagios, E, Gourtsoyiannis, N 1999Effect of lifetime occupational physical activity on indices of bone mineral status in healthy postmenopausal women.Calcif Tissue Int64112116CrossRefPubMedGoogle Scholar
  7. 7.
    Kriska, AM, Sandier, RB, Cauley, JA, LaPorte, RE, Horn, DL, Pambianco, G 1988The assessment of historical physical activity and its relations to adult bone parameters.Am J Epidemiol12710531063PubMedGoogle Scholar
  8. 8.
    Brahm, H, Mallmin, H, Michaelsson, K, Strom, H, Ljunghall, S 1998Relationships between bone mass measurements and lifetime physical activity in a Swedish population.Calcif Tissue Int62400412CrossRefPubMedGoogle Scholar
  9. 9.
    Kemper, HCG, Twisk, J, van Mechelen, W, Post, GB, Roos, JC, Lips, P 2000A fifteen-year longitudinal study in young adults on the relation of physical activity and fitness with the development of the bone mass: the Amsterdam Growth and Health Longitudinal Study.Bone27847853CrossRefPubMedGoogle Scholar
  10. 10.
    Twisk, J, Kemper, HCG, van Mechelen, W 2000Tracking of activity and fitness and the relationship with cardiovascular disease risk factors.Med Sci Sports Exerc3214551461CrossRefPubMedGoogle Scholar
  11. 11.
    Bassey, EJ, Ramsdale, SJ 1995Weight-bearing exercise and ground reaction forces: a 12-month randomized controlled trial of effects on bone mineral density in healthy postmenopausal women.Bone16469476PubMedGoogle Scholar
  12. 12.
    Risser, WI, Lee, EJ, Leblanc, A, Poindexter, HBW, Risser, JMH 1990Bone density in eumenorrheic female college athletes.Med Sci Sports Exerc22570574PubMedGoogle Scholar
  13. 13.
    Dook, JE, James, C, Henderson, NK, Price, RI 1997Exercise and bone mineral density in mature female athletes.Med Sci Sports Exerc29291296PubMedGoogle Scholar
  14. 14.
    Young, N, Formica, C, Szmukler, G, Seeman, E 1994Bone density at weight-bearing and nonweight-bearing sites in ballet dancers: the effects of exercise, hypogonadism, and body weight.J Clin Endocrinol Metab78449454PubMedGoogle Scholar
  15. 15.
    Dalsky, GP, Stocke, KS, Ehsani, AA, Slatopolsky, E, Lee, WL, Birge, SJ 1988Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women.Arch Intern Med108824828Google Scholar
  16. 16.
    Groothausen, J, Siemer, H, Kemper, HCG, Twisk, J, Welten, DC 1997Influence of peak strain on lumbar bone mineral density: an analysis of 15-year physical activity in young males and females.Pediatric Exerc Sci9159173Google Scholar
  17. 17.
    Ainsworth, BE, Haskell, WL, Leon, AS, Montoye, HJ, Sallis, JF, Paffenbarger, JRS 1993Compendium of physical activities: classification of energy costs of human physical activities.Med Sci Sports Exerc257180PubMedGoogle Scholar
  18. 18.
    Sandler, RB, Slemenda, CW, LaPorte, RE, Cauley, JA, Schramm, MM, Barresi, ML, Kriska, AM 1985Postmenopausal bone density and milk consumption in childhood and adolescence.Am J Clin Nutr42270274PubMedGoogle Scholar
  19. 19.
    World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser 843Google Scholar
  20. 20.
    Ulrich, CA, Georgiou, CC, Gillis, DE, Snow, CM 1999Lifetime physical activity is associated with bone mineral density in premenopausal women.J Women’s Health8365375Google Scholar
  21. 21.
    Davee, AM, Rosen, CJ, Adler, RA 1990Exercise patterns and trabecular bone density in college women.J Bone Miner Res5245250PubMedGoogle Scholar
  22. 22.
    Chen, Z, Lohman, TG, Stini, WA, Ritenbaugh, C, Aickin, M 1997Fat or lean tissue mass: Which one is the major determinant of bone mineral mass in healthy postmenopausal women?J Bone Miner Res12144151PubMedGoogle Scholar
  23. 23.
    Galuska, DA, Sowers, MR 1999Menstrual history and bone density in young women.J Womens Health Gend Based Med8647656PubMedGoogle Scholar
  24. 24.
    Chasan-Taber, L, Erickson, JB, McBride, JW, Nasca, PC, Chasan-Taber, S, Freedson, PS 2002Reproducibility of a self-administered lifetime physical activity questionnaire among female college alumnae.Am J Epidemiol155282289CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • L. Micklesfield
    • 1
  • L. Rosenberg
    • 2
  • D. Cooper
    • 3
  • M. Hoffman
    • 3
  • A. Kalla
    • 4
  • I. Stander
    • 5
  • E. Lambert
    • 1
  1. 1.MRC/UCT Research Unit for Exercise Science and Sports MedicineDepartment of Human Biology, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch7700 South Africa
  2. 2.Slone Epidemiology CenterBoston University, Boston, MAUSA
  3. 3.Department of Public Health, Faculty of Health SciencesUniversity of Cape Town, Cape TownSouth Africa
  4. 4.Department of MedicineUniversity of Cape Town, Cape Town South Africa
  5. 5.MRCCape TownSouth Africa

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