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Calcified Tissue International

, Volume 71, Issue 6, pp 493–498 | Cite as

Intrauterine Exposure to a Maternal Low Protein Diet Reduces Adult Bone Mass and Alters Growth Plate Morphology in Rats

  • G. Mehta
  • H.I. Roach
  • S. Langley-Evans
  • P. Taylor
  • I. Reading
  • R.O.C. Oreffo
  • A. Aihie-Sayer
  • N.M.P. Clarke
  • C. Cooper

Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.

Keywords

Animal Model Epidemiological Study Bone Mass Early Life Bone Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 2002

Authors and Affiliations

  • G. Mehta
    • 1
  • H.I. Roach
    • 1
  • S. Langley-Evans
    • 3
  • P. Taylor
    • 4
  • I. Reading
    • 2
  • R.O.C. Oreffo
    • 1
  • A. Aihie-Sayer
    • 2
  • N.M.P. Clarke
    • 1
  • C. Cooper
    • 2
  1. 1.The University Department of Orthopaedic Surgery, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UKGB
  2. 2.MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UKGB
  3. 3.Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UKGB
  4. 4.Department of Medical Physics, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UKGB

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