Experimental Brain Research

, Volume 128, Issue 4, pp 435–440

Intraventricular infusion of the histamine H1 receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344×Brown Norway rats

  • R. U. Hasenöhrl
  • K. Weth
  • J. P. Huston
Research Article

DOI: 10.1007/s002210050866

Cite this article as:
Hasenöhrl, R., Weth, K. & Huston, J. Exp Brain Res (1999) 128: 435. doi:10.1007/s002210050866

Abstract 

In the present study we analyzed the effect of continuous intraventricular infusion of the histamine H1 receptor antagonist d-chlorpheniramine on the performance of 32-month-old Fischer 344/Brown Norway F1 hybrid rats in the place version of the Morris water maze and in two different tests of anxiety (open field and black-and-white exploration). Control groups included vehicle-infused old and adult (3-month-old) F1 hybrids. Chronic infusion of chlorpheniramine improved the maze performance of the old rats and reduced fear-related behaviors in the open field and black-and-white box. Furthermore, long-term administration of chlorpheniramine was found to diminish age-related deficits in motor capacities. The findings substantiate that histamine H1-receptive sites are involved in learning and fear-related processes and indicate that hypomnesia and hyperanxiety seen in the course of brain aging may be based, in part, on hyperactivation of the central histaminergic neuron system. Furthermore, the data contribute to the behavioral characterization of the Fischer 344/Brown Norway F1 hybrid rat in the context of behavioral gerontopharmacology.

Key words H1 receptor Learning Memory Fear Anxiety Water maze Black-and-white exploration Neural plasticity Old rat 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. U. Hasenöhrl
    • 1
  • K. Weth
    • 1
  • J. P. Huston
    • 1
  1. 1.Institute of Physiological Psychology and Center for Biological and Medical Research, University of Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany, e-mail: hasenoeh@uni-duesseldorf.de, Tel: +49 211 81 14299, Fax: +49 211 81 12024DE

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