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Experimental Brain Research

, Volume 118, Issue 1, pp 111–114 | Cite as

Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion

  • E. Knyihár-Csillik
  • János Tajti
  • Mohtasham Samsam
  • Gyula Sáry
  • Péter Buzás
  • László Vécsei
RESEARCH ARTICLE

Abstract 

Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP immunoreactivity as shown by cytophotometric densitomery of the caudal trigeminal nucleus. The decrease in CGRP immunoreactivity is statistically significant only in the medial one-third of the caudal trigeminal nucleus. Since earlier studies have shown that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache.

Key words Caudal trigeminal nucleus Calcitonin generelated peptide Migraine Trigeminal ganglion Electrical stimulation Rat 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • E. Knyihár-Csillik
    • 1
  • János Tajti
    • 1
  • Mohtasham Samsam
    • 1
  • Gyula Sáry
    • 2
  • Péter Buzás
    • 3
  • László Vécsei
    • 1
  1. 1.Department of Clinical Neurology, Albert Szent-Györgyi University Medical School, Semmelweis utca 6, H-6701 Szeged, Hungary Fax: +36-62-455-597, e-mail: knyihar@nepsy.szote.u-szeged.huHU
  2. 2.Department of Physiology, Albert Szent-Györgyi University Medical School, Szeged, HungaryHU
  3. 3.Department of Zoology, Janus Pannonius Univesity, Pe´cs, HungaryHU

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