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Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex

  • Craig D. Workman
  • John Kamholz
  • Thorsten RudroffEmail author
Research Article

Abstract

Transcranial direct current stimulation (tDCS) using intensities ≤ 2 mA on physical and cognitive outcomes has been extensively investigated. Studies comparing the effects of different intensities of tDCS have yielded mixed results and little is known about how higher intensities (> 2 mA) affect outcomes. This study examined the effects of tDCS at 2 mA and 4 mA on leg muscle fatigability. This was a double-blind, randomized, sham-controlled study. Sixteen healthy young adults underwent tDCS at three randomly ordered intensities (sham, 2 mA, 4 mA). Leg muscle fatigability of both legs was assessed via isokinetic fatigue testing (40 maximal reps, 120°/s). Torque- and work-derived fatigue indices (FI-T and FI-W, respectively), as well as total work performed (TW), were calculated. FI-T of the right knee extensors indicated increased fatigability in 2 mA and 4 mA compared with sham (p = 0.01, d = 0.73 and p < 0.001, d = 1.61, respectively). FI-W of the right knee extensors also indicated increased fatigability in 2 mA and 4 mA compared to sham (p = 0.01, d = 0.57 and p < 0.001, d = 1.12, respectively) and 4 mA compared with 2 mA (p = 0.034, d = 0.37). tDCS intensity did not affect TW performed. The 2 mA and 4 mA tDCS intensities increased the fatigability of the right knee extensors in young, healthy participants, potentially from altered motor unit recruitment/discharge rate or cortical hyperexcitability. Despite this increase in fatigability, the TW performed in both these conditions was not different from sham.

Keywords

Non-invasive brain stimulation Transcranial direct current stimulation Muscle fatigue High intensity Isokinetic task 

Notes

Acknowledgements

We thank the study participants for their effort and time. In addition, we thank Emily Jester, Veronica Smith, and Delaney McDowell for their assistance in data collection. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  • Craig D. Workman
    • 1
  • John Kamholz
    • 2
  • Thorsten Rudroff
    • 1
    • 2
    Email author
  1. 1.Department of Health and Human PhysiologyUniversity of IowaIowa CityUSA
  2. 2.Department of NeurologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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