Differential functional patterns of the human posterior cingulate cortex during activation and deactivation: a meta-analytic connectivity model
The posterior cingulate cortex (PCC) has been implicated in a host of cognitive and behavioral processes in addition to serving as a central hub in the default mode network (DMN). Moreover, the PCC has been shown to be involved in a range of psychiatric and neurological disorders. However, very little is known about the specific activated/deactivated functional profiles of the PCC. Here, we employed a dual analytic approach using robust quantitative meta-analytical connectivity modeling (MACM) and ultra-high field, high resolution resting state functional magnetic resonance imaging (rs-fMRI) to identify state-specific functional activity patterns of the human PCC. The MACM results provided evidence for regions of convergence for PCC co-activation and co-deactivation (i.e., left medial frontal gyrus, left amygdala, and left anterior cingulate) as well as regions of divergence specific to either PCC activation (i.e., bilateral inferior frontal gyri) or PCC deactivation (i.e., left parahippocampal gyrus). In addition, exploratory MACMs on dorsal and ventral subregions of the PCC revealed differential functional activity patterns such as greater co-activation of the right PCC and left inferior parietal lobule with the dorsal PCC and greater co-activation of right precuneus with the ventral PCC. Resting state connectivity analyses showed widespread connectivity similar to that of the PCC co-activation-based MACM, but also demonstrated additional regions of activity, including bilateral superior parietal regions and right superior temporal regions. These analyses highlight the diverse neurofunctional repertoire of the human PCC, provide additional insight into its dynamic functional activity patterns as it switches between activated and deactivated states, and elucidates the cognitive processes that may be implicated in clinical populations.
KeywordsBrain Neuroimaging Magnetic resonance imaging Activation analysis Attention
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All authors report having no financial, personal, or organizational conflict of interest with the work outlined in this manuscript.
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The work outlined in this manuscript does not involve the use of human subjects as defined by the Institutional Review Board and no informed consent was necessary.
- Acikalin MY, Gorgolewski KJ, Poldrack RA (2017) A coordinate-based meta-analysis of overlaps in regional specialization and functional connectivity across subjective value and default mode networks. Front Neurosci 11:1–11. https://doi.org/10.3389/fnins.2017.00001 CrossRefPubMedPubMedCentralGoogle Scholar
- Cahill L (2006) Sex-related influences on the neurobiology of emotionally influenced memory. Ann NY Acad Sci 985(1):163–173. https://doi.org/10.1111/j.1749-6632.2003.tb07080.x CrossRefGoogle Scholar
- Cherkassky VL, Kana RK, Keller TA, Just MA (2006) Functional connectivity in a baseline resting-state network in autism. NeuroReport 17(16):1687–1690. https://doi.org/10.1097/01.wnr.0000239956.45448.4c CrossRefPubMedGoogle Scholar
- Eickhoff S, Laird A, Grefkes C, Wang LE, Zilles K, Fox PT (2009) Coordinate-based ALE meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp 30(9):2907–2926. https://doi.org/10.1002/hbm.20718.Coordinate-based CrossRefPubMedPubMedCentralGoogle Scholar
- Gläscher J, Adolphs R, Gläscher J, Adolphs R, Glascher J, Adolphs R (2003) Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala. J Neurosci 23(32):10274–10282. https://doi.org/10.1523/JNEUROSCI.23-32-10274.2003 CrossRefPubMedGoogle Scholar
- Kozlovskiy SA, Nikonova EY, Pyasik MM, Velichkovsky BM (2012) The cingulate cortex and human memory processes. Psychol Russia 5:231Google Scholar
- Leech R, Kamourieh S, Beckmann CF, Sharp DJ (2011) Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control. J Neurosci 31(9):3217–3224. https://doi.org/10.1523/JNEUROSCI.5626-10.2011 CrossRefPubMedPubMedCentralGoogle Scholar
- Liang M, Zhou Y, Jiang T, Liu Z, Tian L, Liu H, Hao Y (2006) Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. NeuroReport 17(2):209–213. https://doi.org/10.1097/01.wnr.0000198434.06518.b8 CrossRefPubMedGoogle Scholar
- Yu C, Zhou Y, Liu Y, Jiang T, Dong H, Zhang Y, Walter M (2011) NeuroImage functional segregation of the human cingulate cortex is con firmed by functional connectivity based neuroanatomical parcellation. NeuroImage 54(4):2571–2581. https://doi.org/10.1016/j.neuroimage.2010.11.018 CrossRefPubMedGoogle Scholar
- Zhu X, Wang X, Xiao J, Liao J, Zhong M, Wang W, Yao S (2012) Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol Psychiat 71(7):611–617. https://doi.org/10.1016/j.biopsych.2011.10.035 CrossRefPubMedGoogle Scholar