Children with autism spectrum disorder have unstable neural responses to sound

  • Sebastian Otto-Meyer
  • Jennifer Krizman
  • Travis White-Schwoch
  • Nina Kraus
Research Article

Abstract

Autism spectrum disorder (ASD) is diverse, manifesting in a wide array of phenotypes. However, a consistent theme is reduced communicative and social abilities. Auditory processing deficits have been shown in individuals with ASD—these deficits may play a role in the communication difficulties ASD individuals experience. Specifically, children with ASD have delayed neural timing and poorer tracking of a changing pitch relative to their typically developing peers. Given that accurate processing of sound requires highly coordinated and consistent neural activity, we hypothesized that these auditory processing deficits stem from a failure to respond to sound in a consistent manner. Therefore, we predicted that individuals with ASD have reduced neural stability in response to sound. We recorded the frequency-following response (FFR), an evoked response that mirrors the acoustic features of its stimulus, of high-functioning children with ASD age 7–13 years. Evident across multiple speech stimuli, children with ASD have less stable FFRs to speech sounds relative to their typically developing peers. This reduced auditory stability could contribute to the language and communication profiles observed in individuals with ASD.

Keywords

Autism spectrum disorder Neural stability Neural variability FFR Auditory Sound processing 

Notes

Acknowledgements

We thank members of the Auditory Neuroscience Laboratory for their assistance with data collection, as well as Trent Nicol and Spencer Benjamin Smith for comments on an earlier draft of the manuscript. We would also like to acknowledge Nicole Russo’s work in collecting the data used for these analyses. This work was supported by Knowles Hearing Center, Northwestern University.

Compliance with ethical standards

Conflict of Interest

None of the authors have potential conflicts of interest to be disclosed.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Sebastian Otto-Meyer
    • 1
    • 2
  • Jennifer Krizman
    • 1
    • 2
  • Travis White-Schwoch
    • 1
    • 2
  • Nina Kraus
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Auditory Neuroscience LaboratoryNorthwestern UniversityEvanstonUSA
  2. 2.Department of Communication SciencesNorthwestern UniversityEvanstonUSA
  3. 3.Institute for NeuroscienceNorthwestern UniversityEvanstonUSA
  4. 4.Department of Neurobiology and PhysiologyNorthwestern UniversityEvanstonUSA
  5. 5.Department of OtolaryngologyNorthwestern UniversityEvanstonUSA

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