Children with autism spectrum disorder have unstable neural responses to sound
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Autism spectrum disorder (ASD) is diverse, manifesting in a wide array of phenotypes. However, a consistent theme is reduced communicative and social abilities. Auditory processing deficits have been shown in individuals with ASD—these deficits may play a role in the communication difficulties ASD individuals experience. Specifically, children with ASD have delayed neural timing and poorer tracking of a changing pitch relative to their typically developing peers. Given that accurate processing of sound requires highly coordinated and consistent neural activity, we hypothesized that these auditory processing deficits stem from a failure to respond to sound in a consistent manner. Therefore, we predicted that individuals with ASD have reduced neural stability in response to sound. We recorded the frequency-following response (FFR), an evoked response that mirrors the acoustic features of its stimulus, of high-functioning children with ASD age 7–13 years. Evident across multiple speech stimuli, children with ASD have less stable FFRs to speech sounds relative to their typically developing peers. This reduced auditory stability could contribute to the language and communication profiles observed in individuals with ASD.
KeywordsAutism spectrum disorder Neural stability Neural variability FFR Auditory Sound processing
We thank members of the Auditory Neuroscience Laboratory for their assistance with data collection, as well as Trent Nicol and Spencer Benjamin Smith for comments on an earlier draft of the manuscript. We would also like to acknowledge Nicole Russo’s work in collecting the data used for these analyses. This work was supported by Knowles Hearing Center, Northwestern University.
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Conflict of Interest
None of the authors have potential conflicts of interest to be disclosed.
- American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders 5th edn. Arlington, VAGoogle Scholar
- Baron-Cohen S, Belmonte MK (2005) Autism: a window onto the development of the social and the analytic brain. Annu Rev Neurosci 28:109–126. https://doi.org/10.1146/annurev.neuro.27.070203.144137 CrossRefPubMedGoogle Scholar
- Boersma P (2006) Praat: doing phonetics by computer. http://www.praat.org/
- Engineer CT, Centanni TM, Im KW, Kilgard MP (2014) Speech sound discrimination training improves auditory cortex responses in a rat model of autism. Front Syst Neurosci 8:. https://doi.org/10.3389/fnsys.2014.00137
- Hall JW (2006) New handbook for auditory evoked responses, 1 edn. Pearson, BostonGoogle Scholar
- Milne E (2011) Increased intra-participant variability in children with autistic spectrum disorders: evidence from single-trial analysis of evoked EEG. Front Psychol 2:. https://doi.org/10.3389/fpsyg.2011.00051
- Rosenhall U, Nordin V, Brantberg K, Gillberg C (2003) Autism and auditory brain stem responses. Ear Hear 24:206–214. https://doi.org/10.1097/01.AUD.0000069326.11466.7E CrossRefPubMedGoogle Scholar
- Rossignol DA, Frye RE (2014) Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol 5:. https://doi.org/10.3389/fphys.2014.00150
- White-Schwoch T, Nicol T, Warrier CM, Abrams DA, Kraus N (2016) Individual differences in human auditory processing: insights from single-trial auditory midbrain activity in an animal model. Cereb Cortex 27(11):5095–5115Google Scholar
- Won H, Mah W, Kim E (2013) Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses. Front Mol Neurosci 6:. https://doi.org/10.3389/fnmol.2013.00019