Experimental Brain Research

, Volume 236, Issue 2, pp 517–527 | Cite as

Ipsilesional functional recruitment within lower mu band in children with unilateral cerebral palsy, an event-related desynchronization study

  • Alberto Inuggi
  • Michela Bassolino
  • Chiara Tacchino
  • Valentina Pippo
  • Valeria Bergamaschi
  • Claudio Campus
  • Valentina De Franchis
  • Thierry Pozzo
  • Paolo Moretti
Research Article


Cerebral palsy (CP) is a group of non-progressive developmental movement disorders inducing a strong brain reorganization in primary and secondary motor areas. Nevertheless, few studies have been dedicated to quantify brain pattern changes and correlate them with motor characteristics in CP children. In this context, it is very important to identify feasible and complementary tools able to enrich the description of motor impairments by considering their neural correlates. To this aim, we recorded the electroencephalographic activity and the corresponding event-related desynchronization (ERD) of a group of mild-to-moderate affected unilateral CP children while performing unilateral reach-to-grasp movements with both their paretic and non-paretic arms. During paretic arm movement execution, we found a reduced ERD in the upper µ band (10–12.5 Hz) over central electrodes, preceded by an increased fronto-central ERD in the lower µ band (7.5–10 Hz) during movement preparation. These changes positively correlated, respectively, with the Modified House Classification scale and the Manual Ability Classification System. The fronto-central activation likely represents an ipsilesional plastic compensatory reorganization, confirming that in not-severely affected CP, the lesioned hemisphere is able to compensate part of the damage effects. These results highlight the importance of analyzing different sub-bands within the classical mu band and suggest that in similar CP population, the lesioned hemisphere should be the target of specific intensive rehabilitation programs.


Cerebral palsy Event-related desynchronization Reach-to-grasp movement Electroencephalography Brain plasticity 



This work was supported by Fondation Motrice ( within the PACE for CP program.

Compliance with ethical standards

Conflict of interest

The authors have stated that they had no interests that might be perceived as posing a conflict or bias.

Supplementary material

221_2017_5149_MOESM1_ESM.pdf (141 kb)
Supplementary material 1 (PDF 140 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Alberto Inuggi
    • 1
  • Michela Bassolino
    • 2
    • 3
  • Chiara Tacchino
    • 4
  • Valentina Pippo
    • 1
  • Valeria Bergamaschi
    • 4
  • Claudio Campus
    • 1
  • Valentina De Franchis
    • 2
  • Thierry Pozzo
    • 1
    • 5
    • 6
  • Paolo Moretti
    • 4
  1. 1.Robotics, Brain and Cognitive Sciences UnitIstituto Italiano di Tecnologia, Center for Human TechnologiesGenoaItaly
  2. 2.Laboratory of Cognitive Neuroscience, Brain Mind InstituteEcole Polytechnique Fédérale de LausanneGenevaSwitzerland
  3. 3.Center for NeuroprostheticsÉcole Polytechnique Fédérale de LausanneGeneveSwitzerland
  4. 4.Physical Medicine and RehabilitationInstitute G. GasliniGenoaItaly
  5. 5.Centro di Neurofisiologia traslazionaleIstituto Italiano di TecnologiaFerraraItaly
  6. 6.INSERM-U1093, Cognition-Action-Plasticité sensorimotriceDijonFrance

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