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Experimental Brain Research

, Volume 234, Issue 2, pp 429–441 | Cite as

Differential neural activity patterns for spatial relations in humans: a MEG study

  • Nicole M. Scott
  • Arthur Leuthold
  • Maria D. Sera
  • Apostolos P. Georgopoulos
Research Article

Abstract

Children learn the words for abovebelow relations earlier than for leftright relations, despite treating these equally well in a simple visual categorization task. Even as adults—conflicts in congruency, such as when a stimulus is depicted in a spatially incongruent manner with respect to salient global cues—can be challenging. Here we investigated the neural correlates of encoding and maintaining in working memory abovebelow and leftright relational planes in 12 adults using magnetoencephalography in order to discover whether abovebelow relations are represented by the brain differently than leftright relations. Adults performed perfectly on the task behaviorally, so any differences in neural activity were attributed to the stimuli’s cognitive attributes. In comparing abovebelow to leftright relations during stimulus encoding, we found the greatest differences in neural activity in areas associated with space and movement. In comparing congruent to incongruent trials, we found the greatest differential activity in premotor areas. For both contrasts, brain areas involved in the encoding phase were also involved in the maintenance phase, which provides evidence that those brain areas are particularly important in representing the relational planes or congruency types throughout the trial. When comparing neural activity associated with the relational planes during working memory, additional right posterior areas were implicated, whereas the congruent-incongruent contrast implicated additional bilateral frontal and temporal areas. These findings are consistent with the hypothesis leftright relations are represented differently than abovebelow relations.

Keywords

Left–right confusion MEG Congruency Relational plane Working memory Encoding 

Notes

Acknowledgments

This study was partially supported by a University of Minnesota Interdisciplinary Doctoral Fellowship, a University of Minnesota Doctoral Dissertation Fellowship (both to NMS), NIH training Grant No. T32 HD007151, the US Department of Veterans Affairs, and the McKnight Presidential Cognitive Neuroscience Chair.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Human subjects/informed consent

The study protocol was approved by the Institutional Review Boards of the Minneapolis VA Medical Center and the University of Minnesota. The study was performed in accordance with the ethical standards outlined in the Declaration of Helsinki. All subjects provided written informed consent prior to participating in the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2015

Authors and Affiliations

  • Nicole M. Scott
    • 1
  • Arthur Leuthold
    • 2
  • Maria D. Sera
    • 1
    • 3
  • Apostolos P. Georgopoulos
    • 1
    • 2
  1. 1.Center for Cognitive SciencesUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of NeuroscienceUniversity of MinnesotaMinneapolisUSA
  3. 3.Institute of Child DevelopmentUniversity of MinnesotaMinneapolisUSA

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