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Experimental Brain Research

, Volume 226, Issue 2, pp 175–182 | Cite as

Eye position dependency of nystagmus during constant vestibular stimulation

  • Christopher J. Bockisch
  • Elham Khojasteh
  • Dominik Straumann
  • Stefan C. A. Hegemann
Research Article

Abstract

Alexander’s law, the eye position dependency of nystagmus due to peripheral vestibular lesions, has been hypothesized to occur due to adaptive changes in the brainstem velocity-to-position neural integrator in response to non-reciprocal vestibular stimulation. We investigated whether it develops during passive head rotations that produce constant nystagmus for >35 s. The yaw rotation stimulus consisted of a 1-s acceleration (100°/s2), followed by a lower acceleration ramp (starting at 7.3°/s2 and increasing at 0.04°/s2/s) until 400°/s was reached after 38 s. This stimulus was designed to offset the ~15 s vestibular ocular reflex time constant (and the 150 s adaptation time constant) and produce constant velocity slow phases. In contrast to peripheral lesions, this vestibular stimulation is the result of real head turns and has the push–pull characteristics of natural movements. The procedure was successful, as the average velocity of 31°/s was unchanged over the final 35 s of the acceleration period. In all 10 healthy human subjects, we found a large and stable Alexander’s law, with an average velocity-versus-position slope of −0.366 in the first half that was not significantly different in the second half, −0.347. These slopes correspond to integrator time constants of <3 s, are much less than normal time constants (~25 s), and are similar to those observed in patients with peripheral vestibular lesions. Alexander’s law also developed, on average, in 10 s. We conclude that Alexander’s law is not simply a consequence of non-reciprocal vestibular stimulation.

Keywords

VOR Nystagmus Vestibular Adaptation Alexander’s law 

Notes

Acknowledgments

We would like to thank Beckey Trihn for collecting data on preliminary experiments and Marco Penner for technical support. This study was financially supported by the Swiss National Science Foundation, the Betty and David Koetser Foundation for Brain Research, Zurich, Switzerland, and the Center of Integrative Human Physiology, University of Zurich, Switzerland. E. Khojasteh receives the FQRNT postdoctoral scholarship from Quebec, Canada.

Supplementary material

221_2013_3423_MOESM1_ESM.pdf (171 kb)
Supplementary material 1 (PDF 171 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Christopher J. Bockisch
    • 1
    • 2
    • 3
    • 4
  • Elham Khojasteh
    • 3
  • Dominik Straumann
    • 1
    • 4
  • Stefan C. A. Hegemann
    • 3
    • 4
  1. 1.Department of NeurologyUniversity Hospital ZürichZurichSwitzerland
  2. 2.Department of OphthalmologyUniversity Hospital ZürichZurichSwitzerland
  3. 3.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity Hospital ZürichZurichSwitzerland
  4. 4.Zürich Centre for Integrative Human Physiology (ZIHP)University Hospital Zürich, University of ZürichZurichSwitzerland

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