Experimental Brain Research

, Volume 219, Issue 2, pp 217–225

Temporal depression of the soleus H-reflex during passive stretch

  • Christopher T. Robertson
  • Koichi Kitano
  • David M. Koceja
  • Zachary A. Riley
Research Article

Abstract

Synaptic efficacy associated with muscle spindle feedback is regulated via depression at the Ia-motoneurone synapse. The inhibitory effects of repetitive Ia afferent discharge on target motoneurones of different sizes were investigated during a passive stretch of ankle extensors in humans. H-reflex recruitment curves were collected from the soleus muscle for two conditions in ten subjects. H-reflexes were elicited during passive stretch at latencies of 50, 100, 300, and 500 ms after a slow (20°/s) dorsiflexion about the right ankle (from 100 to 90°). Control H-reflexes were recorded at corresponding static (without movement) ankle angles of 99, 98, 94, and 90° of flexion. The slope of the H-reflex recruitment curves (Hslp) was then calculated for both conditions. H-reflex values were similar for the static and passive stretch conditions prior to 50–100 ms, not showing the early facilitation typical of increased muscle spindle discharge rates. However, the H-reflex was significantly depressed by 300 ms and persisted through 500 ms. Furthermore, less than 300 ms into the stretch, there was significantly greater H-reflex depression with a lower stimulus intensity (20 % Mmax) versus a higher stimulus intensity (Hmax), though the effects begin to converge at later latencies (>300 ms). This suggests there is a distinct two-stage temporal process in the depression observed in the Ia afferent pathway for all motoneurones during a passive stretch. Additionally, there is not a single mechanism responsible for the depression, but rather both heterosynaptic presynaptic inhibition and homosynaptic post-activation depression are independently influencing the Ia-motoneurone pathway temporally during movement.

Keywords

H-reflex Stretch Post-activation depression Presynaptic inhibition 

References

  1. Brown MC, Matthews PB (1960) The effect on a muscle twitch of the back-response of its motor nerve fibres. J Physiol 150:332–346PubMedGoogle Scholar
  2. Cheng J, Brooke JD, Misiaszek JE, Staines WR (1995) The relationship between the kinematics of passive movement, the stretch of extensor muscles of the leg and the change induced in the gain of the soleus H reflex in humans. Brain Res 672:89–96PubMedCrossRefGoogle Scholar
  3. Crone C, Nielsen J (1989) Methodological implications of the post activation depression of the soleus H-reflex in man. Exp Brain Res 78:28–32PubMedCrossRefGoogle Scholar
  4. Eccles JC, Rall W (1951) Effects induced in a monosynaptic reflex path by its activation. J Neurophysiol 14:353–376PubMedGoogle Scholar
  5. Hilgevoord AA, Koelman JH, Bour LJ, Ongerboer V (1994) Normalization of soleus H-reflex recruitment curves in controls and a population of spastic patients. Electroencephalogr Clin Neurophysiol 93:202–208PubMedCrossRefGoogle Scholar
  6. Houk JC, Rymer WZ, Crago PE (1981) Dependence of dynamic response of spindle receptors on muscle length and velocity. J Neurophysiol 46:143–166PubMedGoogle Scholar
  7. Hugon M (1973) Methodology of the Hoffmann reflex in man. In: Desmedt JE (ed) New developments in electromyography and clinical neurophysiology. Karger, Basel, pp 277–293Google Scholar
  8. Hultborn H, Nielsen JB (1998) Modulation of transmitter release from Ia afferents by their preceding activity—a “postactivation depression”. In: Rudomin P, Romo R, Mendell LM (eds) Presynaptic inhibition and neural control. Oxford University Press, New York, pp 178–191Google Scholar
  9. Hultborn H, Illert M, Nielsen J, Paul A, Ballegaard M, Wiese H (1996) On the mechanism of the post-activation depression of the H-reflex in human subjects. Exp Brain Res 108:450–462PubMedCrossRefGoogle Scholar
  10. Kohn AF, Floeter MK, Hallett M (1997) Presynaptic inhibition compared with homosynaptic depression as an explanation for soleus H-reflex depression in humans. Exp Brain Res 116:375–380PubMedCrossRefGoogle Scholar
  11. Lloyd DPC, Wilson VJ (1957) Reflex depression in rhythmically active monosynaptic reflex pathways. J Gen Physiol 40:409–426PubMedCrossRefGoogle Scholar
  12. Misiaszek JE, Brooke JD, Lafferty KB, Cheng J, Staines WR (1995) Long-lasting inhibition of the human soleus H reflex pathway after passive movement. Brain Res 677:69–81PubMedCrossRefGoogle Scholar
  13. Morita H, Petersen N, Christensen LO, Sinkjaer T, Nielsen J (1998) Sensitivity of H-reflexes and stretch reflexes to presynaptic inhibition in humans. J Neurophysiol 80:610–620PubMedGoogle Scholar
  14. Nielsen J, Petersen N, Crone C (1995) Changes in transmission across synapses of Ia afferents in spastic patients. Brain 118(Pt 4):995–1004PubMedCrossRefGoogle Scholar
  15. Pinniger GJ, Nordlund M, Steele JR, Cresswell AG (2001) H-reflex modulation during passive lengthening and shortening of the human triceps surae. J Physiol 534:913–923PubMedCrossRefGoogle Scholar
  16. Proske U, Morgan DL, Gregory JE (1993) Thixotropy in skeletal muscle and in muscle spindles: a review. Prog Neurobiol 41:705–721PubMedCrossRefGoogle Scholar
  17. Robertson CT, Koceja DM (2003) Post-activation depression of the soleus H-reflex in the elderly. Electromyogr Clin Neurophysiol 43:103–111PubMedGoogle Scholar
  18. Roll JP, Vedel JP (1982) Kinaesthetic role of muscle afferents in man, studied by tendon vibration and microneurography. Exp Brain Res 47:177–190PubMedCrossRefGoogle Scholar
  19. Rudomin P, Schmidt RF (1999) Presynaptic inhibition in the vertebrate spinal cord revisited. Exp Brain Res 129:1–37PubMedCrossRefGoogle Scholar
  20. Trimble MH, Du P, Brunt D, Thompson FJ (2000) Modulation of triceps surae H-reflexes as a function of the reflex activation history during standing and stepping. Brain Res 858:274–283PubMedCrossRefGoogle Scholar
  21. Voigt M, Sinkjaer T (1998) The H-reflex in the passive human soleus muscle is modulated faster than predicted from post-activation depression. Brain Res 783:332–346PubMedCrossRefGoogle Scholar
  22. Wood SA, Gregory JE, Proske U (1996) The influence of muscle spindle discharge on the human H reflex and the monosynaptic reflex in the cat. J Physiol 497(Pt 1):279–290PubMedGoogle Scholar
  23. Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64:355–405PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Christopher T. Robertson
    • 1
    • 2
  • Koichi Kitano
    • 3
  • David M. Koceja
    • 2
  • Zachary A. Riley
    • 2
    • 4
  1. 1.Department of Sport and Exercise ScienceJacksonville UniversityJacksonvilleUSA
  2. 2.Department of Kinesiology & Program in Neural ScienceIndiana UniversityBloomingtonUSA
  3. 3.Department of KinesiologyIndiana UniversityBloomingtonUSA
  4. 4.Department of KinesiologyIndiana University–Purdue UniversityIndianapolisUSA

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