Experimental Brain Research

, Volume 214, Issue 3, pp 463–469 | Cite as

Potentiation of spontaneous and evoked cortical electrical activity after spreading depression: in vivo analysis in well-nourished and malnourished rats

  • Thays Kallyne Marinho de Souza
  • Mariana Barros e Silva
  • André Ricardson Gomes
  • Hélio Magalhães de Oliveira
  • Renato Barros Moraes
  • Catão Temístocles de Freitas Barbosa
  • Rubem Carlos Araújo GuedesEmail author
Research Article


Cortical spreading depression (CSD) is influenced by brain excitability and is related to neurological diseases, such as epilepsy. In vitro evidence indicates that neuronal electrical activity is potentiated after CSD. Malnutrition can cause electrophysiological changes in the brain, both in animals and in humans. Here, we investigated in vivo whether CSD potentiates the amplitude of electrocorticogram (ECoG) and of transcallosal evoked responses in adult well-nourished (W), early-malnourished (M), and food-restricted rats. ECoG amplitudes were compared before and after CSD, at two parietal regions (designated the anterior and posterior regions). In the anterior region, post-CSD amplitudes of the ECoG waves were 13–23% higher (P < 0.05) than the pre-CSD values in all groups. In the posterior region, amplitudes increased 22% in the M group only (P < 0.05). In a fourth CSD-free group, ECoG amplitude did not change during the four recording hours. Transcallosal electrically evoked cortical responses also increased 21.5 ± 9.6% and 41.8 ± 28.5%, after CSD, in the W and M conditions, respectively, as compared to pre-CSD values. The data support the hypothesis of an in vivo CSD potentiation on cortical excitability as recorded by spontaneous and evoked electrical activity and modulation by nutritional status.


Brain excitability Cerebral cortex EEG Rat Transcallosal responses 



This work was supported by CAPES (Procad/2007), CNPq (INCT de Neurociência Translacional—No. 573604/2008-8), MS/SCTIE/DECIT (No. 17/2006), Facepe (APQ0975-4.05/08), and IBN-Net/Finep (No. 4191) for financial support. R.C.A. Guedes is Research Fellow from CNPq (No. 301190/2010-0).

Conflict of interest

None declared.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Thays Kallyne Marinho de Souza
    • 1
  • Mariana Barros e Silva
    • 1
  • André Ricardson Gomes
    • 2
  • Hélio Magalhães de Oliveira
    • 2
  • Renato Barros Moraes
    • 3
  • Catão Temístocles de Freitas Barbosa
    • 3
  • Rubem Carlos Araújo Guedes
    • 1
    Email author
  1. 1.Departamento de NutriçãoUniversidade Federal de PernambucoRecifeBrazil
  2. 2.Departamento de Eletrônica e SistemasUniversidade Federal PernambucoRecifeBrazil
  3. 3.Universidade Federal Rural de PernambucoRecifeBrazil

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