Event-related desynchronization of motor cortical oscillations in patients with multiple system atrophy
- 211 Downloads
Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism (MSA-P), cerebellar and autonomic deficits. In Parkinson’s disease (PD), an impaired modulation of motor cortical mu and beta range oscillations may be related to the pathophysiology of bradykinesia. Event-related desynchronization (ERD) of these oscillations occur for 1–2 s preceding a voluntary movement in normal subjects and patients with PD treated with levodopa while only lasting around 0.5 s in untreated patients. Motor cortical rhythms were recorded from subdural strip electrodes in three patients with MSA-P while taking their regular dopaminergic medications. Following a ready cue, patients performed an externally cued wrist extension movement to a go cue. In addition, recordings were obtained during imagined wrist extension movements to the same cues and during self-paced wrist extensions. ERD and event-related synchronization were examined in subject-specific frequency bands. All patients showed movement-related ERD in subject-specific frequency bands below ~40 Hz in both externally cued and self-paced conditions. Preparatory ERD latency preceding self-cued movement was 900 ms in one patient and at or after movement onset in the other two patients. In the externally cued task, a short lasting (<1.3 s) ready cue-related ERD that was not sustained to movement onset was observed in two patients. Imagined movements resulted in go cue-related ERD with a smaller magnitude in the same two patients. These results indicate that the modulation of motor cortical oscillations in patients with MSA that are treated with levodopa is similar to that occurring in untreated patients with PD. The findings suggest that cortical activation in patients with MSA is diminished, may be related to pathophysiological changes occurring in the basal ganglia and correlates with the poor clinical response that these patients typically obtain with dopaminergic therapy.
KeywordsMultiple system atrophy Parkinson’s disease Event-related desynchronization Mu rhythm Beta rhythm
Multiple system atrophy
MSA with parkinsonian symptoms
United Parkinson’s disease rating scale
Magnetic resonance imaging
We thank Dr. Peter Ashby from the Toronto Western Research Institute for assistance with the electrophysiological recordings. Funding was provided by grants from the Canadian Institutes of Health Research MOP 42505 and US NIH DE40872 to JOD. AML is a Tier 1 Canada Research Chair in Neuroscience.
- Defebvre L, Bourriez JL, Derambure P, Duhamel A, Guieu JD, Destee A (1998) Influence of chronic administration of L-DOPA on event-related desynchronization of mu rhythm preceding voluntary movement in Parkinson’s disease. Electroencephalogr Clin Neurophysiol 109(2):161–167CrossRefPubMedGoogle Scholar
- Geser F, Wenning GK, Seppi K, Stampfer-Kountchev M, Scherfler C, Sawires M, Frick C, Ndayisaba JP, Ulmer H, Pellecchia MT, Barone P, Kim HT, Hooker J, Quinn NP, Cardozo A, Tolosa E, Abele M, Klockgether T, Østergaard K, Dupont E, Schimke N, Eggert KM, Oertel W, Djaldetti R, Poewe W, the European MSA Study Group (2006) Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG). Mov Disord 21(2):179–186CrossRefPubMedGoogle Scholar
- Gilman S, Low P, Quinn N, Albanese A, Ben-Shlomo Y, Fowler C, Kaufmann H, Klockgether T, Lang A, Lantos P, Litvan I, Mathias C, Oliver E, Robertson D, Schatz I, Wenning G (1998) Consensus statement on the diagnosis of multiple system atrophy. American autonomic society and american academy of neurology. Clin Auton Res 8(6):359–362CrossRefPubMedGoogle Scholar
- Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ, Oliver E, Robertson D, Schatz I, Wenning GK (1999) Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 163(1):94–98CrossRefPubMedGoogle Scholar
- Marceglia S, Bianchi AM, Baselli G, Foffani G, Cogiamanian F, Modugno N, Mrakic-Sposta S, Priori A, Cerutti S (2007) Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials. IEEE Trans Neural Syst Rehabil Eng 15(4):483–492CrossRefPubMedGoogle Scholar
- Priori A, Foffani G, Pesenti A, Bianchi A, Chiesa V, Baselli G, Caputo E, Tamma F, Rampini P, Egidi M, Locatelli M, Barbieri S, Scarlato G (2002) Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson’s disease. Neurol Sci 23(2):S101–S102CrossRefPubMedGoogle Scholar
- Talmant V, Esposito P, Stilhart B, Mohr M, Tranchant C (2006) Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report. Rev Neurol (Paris) 162(3):363–370Google Scholar