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Mirror neurons: from discovery to autism

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References

  1. Altschuler EL, Vankov A, Wang V, Ramachandran VS, Pineda JA (1997) Person see, person do: human cortical electrophysiological correlates of monkey see monkey do cell [abstract 719.17]. Presented at the annual meeting of the society for neuroscience, New Orleans, 25–30 October 1997

  2. Altschuler EL, Vankov A, Hubbard EM, Roberts E, Ramachandran VS, Pineda JA (2000) Mu wave blocking by observation of movement and its possible use as a tool to study theory of other minds [abstract 67.23]. Presented at the 30th annual meeting of the society for neuroscience, New Orleans, 4–9 November 2000

  3. Avikainen S, Wohlschläger A, Liuhanen S, Hänninen R, Hari R (2003) Impaired mirror-image imitation in Asperger and high-funtioning autistic subjects. Curr Biol 13:339–341

  4. Bird G, Leighton J, Press C, Heyes C (2007) Intact automatic imitation of human and robot actions in autism spectrum disorders. Proc Biol Sci. 274:3027–3031

  5. Boria S, Fabbri-Destro M, Cattaneo L, Sparaci L, Sinigaglia C, Santelli E, Cossu G, Rizzolatti G (2009) Intention understanding in autism. PLoS ONE 4:e5596

  6. Borroni P, Montagna M, Cerri G, Baldissera F (2005) Cyclic time course of motor excitability modulation during observation of a cyclic hand movement. Brain Res 1065:115–124

  7. Brass M, Schmitt RM, Spengler S, Gergely G (2007) Investigating action understanding: inferential processes versus action simulation. Curr Biol 17:2117–2121

  8. Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ (2001) Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study. Eur J Neurosci 13:400–404

  9. Buccino G, Vogt S, Ritzl A, Fink G, Zilles K, Freund H, Rizzolatti G (2004a) Neural circuits underlying imitation learning of hand actions: an event-related fMRI study. Neuron 42:323–334

  10. Buccino G, Lui F, Canessa N, Patteri I, Lagravinese G, Benuzzi F, Porro CA, Rizzolatti G (2004b) Neural circuits involved in the recognition of actions performed by non-conspecifics: an fMRI study. J Cogn Neurosci 16:114–126

  11. Buccino G, Baumgaertner A, Colle L, Buechel C, Rizzolatti G, Binkofski F (2007) The neural basis for understanding non-intended actions. Neuroimage 36(Suppl 2):T119–T127

  12. Byrne RW (2002) Seeing actions as hierarchically organized structures: great ape manual skills. In: Meltzoff AN, Prinz W (eds) The imitative mind. Development, evolution, brain bases. Cambridge University Press, Cambridge, UK, pp 122–140

  13. Caggiano V, Fogassi L, Rizzolatti G, Thier P, Casile A (2009) Mirror neurons differentially encode the peripersonal and extrapersonal space of monkeys. Science 324:403–406

  14. Calvo-Merino B, Glaser DE, Grèzes J, Passingham RE, Haggard P (2005) Action observation and acquired motor skills: an fMRI study with expert dancers. Cereb Cortex 15:1243–1249

  15. Calvo-Merino B, Grèzes J, Glaser D, Passingham R, Haggard P (2006) Seeing or doing? Influence of visual and motor familiarity in action observation. Curr Biol 16:1905–1910

  16. Catmur C, Walsh V, Heyes C (2007) Sensorimotor learning configures the human mirror system. Curr Biol 17:1527–1531

  17. Catmur C, Gillmeister H, Bird G, Liepelt R, Brass M, Heyes C (2008) Through the looking glass: counter-mirror activation following incompatible sensorimotor learning. Eur J Neurosci 28:1208–1215

  18. Cattaneo L, Rizzolatti G (2009) The mirror neuron system. Arch Neurol 66:557–560

  19. Cattaneo L, Fabbri-Destro M, Boria S, Pieraccini C, Monti A, Cossu G, Rizzolatti G (2007) Impairment of actions chains in autism and its possible role in intention understanding. Proc Natl Acad Sci USA 104:17825–17830

  20. Chong TT, Cunnington R, Williams MA, Kanwisher N, Mattingley JB (2008) fMRI adaptation reveals mirror neurons in human inferior parietal cortex. Curr Biol 18:1576–1580

  21. Cochin S, Barthelemy C, Roux S, Martineau J (1999) Observation and execution of movement: similarities demonstrated by quantified electroencephalography. Eur J Neurosci 11:1839–1842

  22. Crammond DJ, Kalaska JF (2000) Prior information in motor and premotor cortex: activity during the delay period and effect on pre-movement activity. J Neurophysiol 84:986–1005

  23. Cross ES, de Hamilton AF, Grafton ST (2006) Building a motor simulation de novo: observation of dance by dancers. Neuroimage 31:1257–1267

  24. Csibra G, Gergely G (2007) ‘Obsessed with goals’: functions and mechanisms of teleological interpretation of actions in humans. Acta Psychol 124:60–78

  25. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, Iacoboni M (2006) Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci 9:28–30

  26. de Lange FP, Spronk M, Willems RM, Toni I, Bekkering H (2008) Complementary systems for understanding action intentions. Curr Biol 18:454–457

  27. Di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G (1992) Understanding motor events: a neurophysiological study. Exp Brain Res 91:176–180

  28. Dinstein I (2008) Human cortex: reflections of mirror neuron. Curr Biol 18:R956–R959

  29. Dinstein I, Gardner JL, Jazayeri M, Heeger DJ (2008) Executed and observed movements have different distributed representations in human aIPS. J Neurosci 28:11231–11239

  30. DSM-IV-TR (2000) American Psychiatric Association [APA], 4th edn

  31. Etzel JA, Gazzola V, Keysers C (2008) Testing simulation theory with cross-modal multivariate classification of fMRI data. PLoS One 3:e3690

  32. Fabbri-Destro M, Rizzolatti G (2008) The mirror system in monkeys and humans. Physiology 23:171–179

  33. Fadiga L, Fogassi L, Pavesi G, Rizzolatti G (1995) Motor facilitation during action observation: a magnetic stimulation study. J Neurophysiol 73:2608–2611

  34. Ferrari PF, Visalberghi E, Paukner A, Fogassi L, Ruggiero A, Suomi SJ (2006) Neonatal imitation in rhesus macaques. PLoS Biol 4:e302

  35. Filimon F, Nelson JD, Hagler DJ, Sereno MI (2007) Human cortical representations for reaching: mirror neurons for execution, observation, and imagery. Neuroimage 37:1315–1328

  36. Fogassi L, Ferrari PF, Gesierich B, Rozzi S, Chersi F, Rizzolatti G (2005) Parietal lobe: from action organization to intention understanding. Science 308:662–667

  37. Frith CD, Frith U (1999) Interacting minds—a biological basis. Science 286:1692–1695

  38. Gallese V, Keysers C, Rizzolatti G (2004) A unifying view of the basis of social cognition. Trends Cogn Sci 8:396–403

  39. Gangitano M, Mottaghy FM, Pascual-Leone A (2001) Phase specific modulation of cortical motor output during movement observation. NeuroReport 12:1489–1492

  40. Gastaut HJ, Bert J (1954) EEG changes during cinematographic presentation; moving picture activation of the EEG. Electroencephalogr Clin Neurophysiol 6:433–444

  41. Gazzola V, Keysers C (2009) The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data. Cereb Cortex 19:1239–1255

  42. Gazzola V, Aziz-Zadeh L, Keysers C (2006) Empathy and the somatotopic auditory mirror system in humans. Curr Biol 16:1824–1829

  43. Gazzola V, Rizzolatti G, Wicker B, Keysers C (2007a) The anthropomorphic brain: The mirror neuron system responds to human and robotic actions. Neuroimage 35:1674–1684

  44. Gazzola V, van der Worp H, Mulder T, Wicker B, Rizzolatti G, Keysers C (2007b) Aplasics born without hands mirror the goal of hand actions with their feet. Curr Biol 17:1235–1240

  45. Grafton ST, Arbib MA, Fadiga L, Rizzolatti G (1996) Localization of grasp representations in humans by PET: 2. Observation compared with imagination. Exp Brain Res 112:103–111

  46. Grèzes J, Armony JL, Rowe J, Passingham RE (2003) Activations related to “mirror” and “canonical” neurones in the human brain: an fMRI study. Neuroimage 18:928–937

  47. Hamilton AF, Grafton ST (2006) Goal representation in human anterior intraparietal sulcus. J Neurosci 26:1133–1137

  48. Hamilton AF, Grafton ST (2008) Action outcomes are represented in human inferior frontoparietal cortex. Cereb Cortex 18:1160–1168

  49. Hamilton AF, Brindley RM, Frith U (2007) Imitation and action understanding in autistic spectrum disorders: how valid is the hypothesis of a deficit in the mirror neuron system? Neuropsychologia 45:1859–1868

  50. Hari R, Forss N, Avikainen S, Kirveskari S, Salenius S, Rizzolatti G (1998) Activation of human primary motor cortex during action observation: a neuromagnetic study. Proc Natl Acad Sci USA 95:15061–15065

  51. Heiser M, Iacoboni M, Maeda F, Marcus J, Mazziotta JC (2003) The essential role of Broca’s area in imitation. Eur J Neurosci 17:1123–1128

  52. Hyvarinen J (1982) Posterior parietal lobe of the primate brain. Physiol Rev 62:1060–1129

  53. Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G (1999) Cortical mechanisms of human imitation. Science 286:2526–2528

  54. Iacoboni M, Molnar-Szakacs I, Gallese V, Buccino G, Mazziotta JC, Rizzolatti G (2005) Grasping the intentions of others with one’s own mirror neuron system. PLoS Biol 3:e79

  55. Ishida H, Nakajima K, Inase M, Murata A (2009) Shared mapping of own and others’ bodies in visuotactile bimodal area of monkey parietal cortex. J Cogn Neurosci (Epub ahead of print)

  56. Jacob P, Jeannerod M (2005) The motor theory of social cognition: a critique. Trends Cogn Sci 9:21–25

  57. Jeannerod M, Arbib MA, Rizzolatti G, Sakata H (1995) Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci 18:314–320

  58. Kakei S, Hoffman DS, Strick PL (1999) Muscle and movement representations in the primary motor cortex. Science 1999(285):2136–2139

  59. Kakei S, Hoffman DS, Strick PL (2001) Direction of action is represented in the ventral premotor cortex. Nat Neurosci 4:1020–1025

  60. Kalaska JF, Crammond DJ (1995) Deciding not to GO: neuronal correlates of response selection in a GO/NOGO task in primate premotor and parietal cortex. Cereb Cortex 5:410–428

  61. Kanner L (1943) Autistic disturbances of affective contact. Nerv Child 2:217–225

  62. Kilner JM, Neal A, Weiskopf N, Friston KJ, Frith CD (2009) Evidence of mirror neurons in human frontal gyrus. J Neurosci 29:10153–10159

  63. Knoblich G, Prinz W (2005) Linking perception and action: an ideomotor approach. In: Freund H-J, Jeannerod M, Hallett M, Leiguarda R (eds) Higher-order motor disorders. Oxford University Press, Oxford

  64. Leighton J, Bird G, Charman T, Heyes C (2008) Weak imitative performance is not due to a functional ‘mirroring’ deficit in adults with autism spectrum disorders. Neuropsychologia 46:1041–1049

  65. Liepelt R, Von Cramon DY, Brass M (2008) How do we infer others’ goals from non-stereotypic actions? The outcome of context-sensitive inferential processing in right inferior parietal and posterior temporal cortex. Neuroimage 43:784–792

  66. Lingnau A, Gesierich B, Caramazza A (2009) Asymmetric fMRI adaptation reveals no evidence for mirror neurons in humans. Proc Natl Acad Sci USA 106:9925–9930

  67. Logothetis NK (2008) What we can do and what we cannot do with fMRI. Nature 453:869–878

  68. Lui F, Buccino G, Duzzi D, Benuzzi F, Crisi G, Baraldi P, Nichelli P, Porro CA, Rizzolatti G (2008) Neural substrates for observing and imagining non object-directed actions. Soc Neurosci 3:261–275

  69. Maeda F, Kleiner-Fisman G, Pascual-Leone A (2002) Motor facilitation while observing hand actions: specificity of the effect and role of observer’s orientation. J Neurophysiol 87:1329–1335

  70. Marshall PJ, Bouquet CA, Shipley TF, Young T (2009) Effects of brief imitative experience on EEG desynchronization during action observation. Neuropsychologia 47:2100–2106

  71. Martineau J, Cochin S, Magne R, Barthelemy C (2008) Impaired cortical activation in autistic children: is the mirror neuron system involved? Int J Psychophysiol 68:35–40

  72. Meltzoff AN, Moore MK (1979) Interpreting “imitative” responses in early infancy. Science 205:217–219

  73. Minshew NJ, Williams DL (2007) The new neurobiology of autism: cortex, connectivity, and neuronal organization. Arch Neurol 64:945–950

  74. Mitchell JP (2008) Activity in right temporo-parietal junction is not selective for theory-of-mind. Cereb Cortex 18:262–271

  75. Murata A, Fadiga L, Fogassi L, Gallese V, Raos V, Rizzolatti G (1997) Object representation in the ventral premotor cortex (area F5) of the monkey. J Neurophysiol 78:2226–2230

  76. Nelissen K, Luppino G, Vanduffel W, Rizzolatti G, Orban GA (2005) Observing others: multiple action representation in the frontal lobe. Science 310:332–336

  77. Nishitani N, Avikainen S, Hari R (2004) Abnormal imitation-related cortical activation sequences in Asperger’s syndrome. Ann Neurol 55:558–562

  78. Oberman LM, Hubbard EM, McCleery JP, Altschuler EL, Ramachandran VS, Pineta JA (2005) EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Brain Res Cogn Brain Res 24:190–198

  79. Peeters R, Simone L, Nelissen K, Fabbri-Destro M, Vanduffel W, Rizzolatti G, Orban GA (2009) The representation of tool use in humans and monkeys: common and unique human features. J. Neuroscience 76:207–214

  80. Penfield W, Rasmussen T (1950) The cerebral cortex of man. Macmillan, New York

  81. Prather JF, Peters S, Nowicki S, Mooney R (2008) Precise auditory-vocal mirroring in neurons for learned vocal communication. Nature 451:305–310

  82. Ramachandran VS, Oberman LM (2006) Broken mirrors: a theory of autism. Sci Am 295:62–69

  83. Rizzolatti G (2005) The mirror neuron system and imitation. In: Hurley S, Chater N (eds) Perspectives on Imitation, vol 1. MIT press, Cambridge

  84. Rizzolatti G, Arbib MA (1998) Language within our grasp. Trends Neurosci 21:188–194

  85. Rizzolatti G, Craighero L (2004) The mirror-neuron system. Annu Rev Neurosci 27:169–192

  86. Rizzolatti G, Camarda R, Fogassi L, Gentilucci M, Luppino G, Matelli M (1988) Functional organization of inferior area 6 in the macaque monkey. II. Area F5 and the control of distal movement. Exp Brain Res 71:491–507

  87. Rizzolatti G, Fadiga L, Matelli M, Bettinardi V, Paulesu E, Perani D, Fazio F (1996) Localization of grasp representations in human by PET: 1. Observation versus execution. Exp Brain Res 111:246–252

  88. Rizzolatti G, Fabbri-Destro M, Cattaneo L (2009) Mirror neurons and their clinical relevance. Nat Clin Pract Neurol 5:24–34

  89. Rozzi S, Ferrari PF, Bonini L, Rizzolatti G, Fogassi L (2008) Functional organization of inferior parietal lobule convexity in the macaque monkey: electrophysiological characterization of motor, sensory and mirror responses and their correlation with cytoarchitectonic areas. Eur J Neurosci 28:1569–1588

  90. Sakata H, Taira M, Murata A, Mine S (1995) Neural mechanisms of visual guidance of hand action in the parietal cortex of the monkey. Cereb Cortex 5:429–438

  91. Sakreida K, Schubotz RI, Wolfensteller U, von Cramon DY (2005) Motion class dependency in observers’ motor areas revealed by functional magnetic resonance imaging. J Neurosci 25:1335–1342

  92. Sawamura H, Orban GA, Vogels R (2006) Selectivity of neuronal adaptation does not match response selectivity: a single-cell study of the FMRI adaptation paradigm. Neuron 49:307–318

  93. Saxe R, Powell LJ (2006) It’s the thought that counts: specific brain regions for one component of theory of mind. Psychol Sci 17:692–699

  94. Saxe R, Wexler A (2005) Making sense of another mind: the role of the right temporo-parietal junction. Neuropsychologia 43:1391–1399

  95. Scholz J, Triantafyllou C, Whitfield-Gabrieli S, Brown EN, Saxe R (2009) Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS ONE 4:e4869

  96. Shepherd SV, Klein JT, Deaner RO, Platt ML (2009) Mirroring of attention by neurons in macaque parietal cortex. Proc Natl Acad Sci USA 106:9489–9494

  97. Southgate V, Hamilton AF (2008) Unbroken mirrors: challenging a theory of autism. Trends Cogn Sci 12:225–229

  98. Stefan K, Cohen LG, Duque J, Mazzocchio R, Celnik P, Sawaki L, Ungerleider L, Classen J (2005) Formation of a motor memory by action observation. J Neurosci 25:9339–9346

  99. Stefan K, Classen J, Celnik P, Cohen LG (2008) Concurrent action observation modulates practice-induced motor memory formation. Eur J Neurosci 27:730–738

  100. Strafella AP, Paus T (2000) Modulation of cortical excitability during action observation: a transcranial magnetic stimulation study. NeuroReport 11:2289–2292

  101. Theoret H, Halligan E, Kobayashi M, Fregni F, Tager-Flusberg H, Pascual-Leone A (2005) Impaired motor facilitation during action observation in individuals with autism spectrum disorder. Curr Biol 15:R84–R85

  102. Umiltà MA, Escola L, Intskirveli I, Grammont F, Rochat M, Caruana F, Jezzini A, Gallese V, Rizzolatti G (2008) When pliers become fingers in the monkey motor system. Proc Natl Acad Sci USA 105:2209–2213

  103. Visalberghi E, Fragaszy DM (1990) Do monkeys ape? In: Parker ST, Gibson KR (eds) “Language” and intelligence in monkeys and apes. Cambridge University Press, Cambridge, pp 247–273

  104. Vogt S, Buccino G, Wohlschlager AM, Canessa N, Shah NJ, Zilles K, Eickhoff SB, Freund HJ, Rizzolatti G, Fink GR (2007) Prefrontal involvement in imitation learning of hand actions: effects of practice and expertise. Neuroimage 37:1371–1383

  105. Wheaton KJ, Thompson JC, Syngeniotis A, Abbott DF, Puce A (2004) Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. Neuroimage 22:277–288

  106. Williams JHG, Whiten A, Suddendorf T, Perrett DI (2001) Imitation, mirror neurons and autism. Neurosci Biobehav Rev 25:287–295

  107. Woolsey CN, Settlage PH, Meyer DR, Sencer W, Pinto Hamuy T, Travis AM (1952) Patterns of localization in precentral and “supplementary” motor areas and their relation to the concept of a premotor area. Res Publ Assoc Res Nerv Ment Dis 30:238–264

  108. Zentall TR (2006) Imitation: definitions, evidence, and mechanisms. Anim Cogn 9:335–353

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Acknowledgments

The study was supported by Fondazione Monte Parma and by a grant (FIL) of the University of Parma to GR. M.F-D. was supported by Fondazione Cassa di Risparmio di Ferrara. We thank Rachel Wood for her comments on the article.

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Correspondence to Giacomo Rizzolatti.

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Rizzolatti, G., Fabbri-Destro, M. Mirror neurons: from discovery to autism. Exp Brain Res 200, 223–237 (2010) doi:10.1007/s00221-009-2002-3

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Keywords

  • Autistic Spectrum Disorder
  • Transcranial Magnetic Stimulation
  • Typically Develop
  • Inferior Frontal Gyrus
  • Mirror Neuron