Experimental Brain Research

, Volume 186, Issue 3, pp 409–417

Cathodal transcranial direct current stimulation on posterior parietal cortex disrupts visuo-spatial processing in the contralateral visual field

Research Article

DOI: 10.1007/s00221-007-1245-0

Cite this article as:
Schweid, L., Rushmore, R.J. & Valero-Cabré, A. Exp Brain Res (2008) 186: 409. doi:10.1007/s00221-007-1245-0


Transcranial direct current stimulation (tDCS) has recently undergone a resurgence in popularity as a powerful tool to non-invasively manipulate brain activity. While tDCS has been used to alter functions tied to primary motor and visual cortices, its impact on extrastriate visual areas involved in visuo-spatial processing has not yet been examined. In the current study, we applied tDCS to the cat visuoparietal (VP) cortex and assayed performance in a paradigm designed to assess the capacity to detect, localize and orient to static targets appearing at different spatial eccentricities within the visual field. Real or sham cathodal tDCS was unilaterally applied to the VP cortex, and orienting performance was assessed during (online), immediately after (offline; Experiments 1 and 2), and 1 or 24 h after the end of the tDCS stimulation (Experiment 2). Performance was compared to baseline data collected immediately prior to stimulation. Real, but not sham, tDCS induced significant decreases in performance for static visual targets presented in the contrastimulated visual hemifield. The behavioral impact of tDCS was most apparent during the online and immediate offline periods. The tDCS effect decayed progressively over time and performance returned to baseline levels ∼60 min after stimulation. These results are consistent with the effects of both invasive and non-invasive deactivation methods applied to the same brain region, and indicate that tDCS has the potential to modify neuronal activity in extrastriate visual regions and to sculpt brain activity and behavior in normal and neurologically impaired subjects.


Posterior parietal cortex Plasticity Visuo-spatial attention Neglect Neuromodulation Direct current Brain polarization 

Supplementary material

221_2007_1245_MOESM1_ESM.doc (32 kb)
Supplementary Methods: (DOC 32 kb)
221_2007_1245_MOESM2_ESM.jpg (204 kb)
Supplementary Figure 1. Impact of transcranial direct current stimulation (tDCS) on orienting performance to moving stimuli. Performances for stimuli presented at each eccentricity are shown for baseline assessment (white bars), during tDCS (black bars) and immediately following tDCS (gray bars). Values represent mean values (n=3) and error bars represent the standard error of the mean. (JPG 204 kb)

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • L. Schweid
    • 2
  • R. J. Rushmore
    • 1
  • A. Valero-Cabré
    • 1
    • 3
    • 4
  1. 1.Laboratory for Cerebral Dynamics, Plasticity and Rehabilitation, Department of Anatomy and NeurobiologyBoston University School of MedicineBostonUSA
  2. 2.Graduate Program in Medical Sciences, Graduate Division of Medical SciencesBoston UniversityBostonUSA
  3. 3.Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center and Department of NeurologyHarvard Medical SchoolBostonUSA
  4. 4.LPNC, UMR 5105-CNRS, Grenoble, Treat Vision, Department of NeurologyFondation Ophtalmologique RothschildParisFrance

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