Experimental Brain Research

, Volume 183, Issue 1, pp 133–138 | Cite as

The amplitude and phase precision of 40 Hz auditory steady-state response depend on the level of arousal

  • Inga Griskova
  • Morten Morup
  • Josef Parnas
  • Osvaldas Ruksenas
  • Sidse M. Arnfred
Research Note

Abstract

The aim of this study was to investigate, in healthy subjects, the modulation of amplitude and phase precision of the auditory steady-state response (ASSR) to 40 Hz stimulation in two resting conditions varying in the level of arousal. Previously, ASSR measures have shown to be affected by the level of arousal, but the findings are somewhat controversial. Generally, ASSR is diminished in sleep but it may be increased in drowsiness. Besides, ASSR reduction has been observed in schizophrenia. However, schizophrenic patients are known to have a disturbance of arousal level, what makes it pertinent to know the effects of fluctuations in arousal on passive response to gamma-range stimulation. In nine healthy volunteers trains of 40 Hz click stimuli were applied during two conditions: in the “high arousal” condition subjects were sitting upright silently reading a book of interest; in the “low arousal” condition subjects were sitting in a reclined position with eyes closed and the lights turned off. The 64-channel EEG data was wavelet transformed and the amplitude and phase precision of the wavelet transformed evoked potential were decomposed by the recently proposed multi-subject non-negative multi-way factorization (NMWF) (Morup et al. in J Neurosci Methods 161:361–368, 2007). The estimates of these measures were subjected to statistical analysis. The amplitude and phase precision of the ASSR were significantly larger during the low arousal state compared to the high arousal condition. The modulation of ASSR amplitude and phase precision by differences in the arousal level during recording warrants caution when investigating oscillatory brain activity and interpreting the findings of reduced ASSR in schizophrenia. It also emphasizes the necessity of standardized recording procedures and monitoring the level of arousal during ASSR testing.

Keywords

Steady-state response Auditory Multi-way matrix factorization Arousal 

References

  1. Bernstein AS (1987) Orienting response research in schizophrenia: where we have come and where we might go. Schizophr Bull 13:623–641PubMedGoogle Scholar
  2. Brenner CA, Sporns O, Lysaker PH, O’Donnell BF (2003) EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder. Am J Psychiatry 160:2238–2240PubMedCrossRefGoogle Scholar
  3. Cannon TD, Fuhrmann M, Mednick SA, Machon RA, Parnas J, Schulsinger F (1988) Third ventricle enlargement and reduced electrodermal responsiveness. Psychophysiology 25:153–156PubMedCrossRefGoogle Scholar
  4. Cardenas VA, Gill P, Fein G (1997) Human P50 suppression is not affected by variations in wakeful alertness. Biol Psychiatry 41:891–901PubMedCrossRefGoogle Scholar
  5. Cohen LT, Rickards FW, Clark GM (1991) A comparison of steady-state evoked potentials to modulated tones in awake and sleeping humans. J Acoust Soc Am 90:2467–2479PubMedCrossRefGoogle Scholar
  6. Delorme A, Makeig S (2004) EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 134:9–21PubMedCrossRefGoogle Scholar
  7. Galambos R, Makeig S, Talmachoff PJ (1981) A 40-Hz auditory potential recorded from the human scalp. Proc Natl Acad Sci USA 78:2643–2647PubMedCrossRefGoogle Scholar
  8. Gottesmann C (1999) Neurophysiological support of consciousness during waking and sleep. Prog Neurobiol 59:469–508PubMedCrossRefGoogle Scholar
  9. Hari R, Hamalainen M, Joutsiniemi SL (1989) Neuromagnetic steady-state responses to auditory stimuli. J Acoust Soc Am 86:1033–1039PubMedCrossRefGoogle Scholar
  10. Hong LE, Summerfelt A, McMahon R, Adami H, Francis G, Elliott A, Buchanan RW, Thaker GK (2004) Evoked gamma band synchronization and the liability for schizophrenia. Schizophr Res 70:293–302PubMedCrossRefGoogle Scholar
  11. Jerger J, Chmiel R, Frost JD Jr, Coker N (1986) Effect of sleep on the auditory steady state evoked potential. Ear Hear 7:240–245PubMedCrossRefGoogle Scholar
  12. Kwon JS, O’Donnell BF, Wallenstein GV, Greene RW, Hirayasu Y, Nestor PG, Hasselmo ME, Potts GF, Shenton ME, McCarley RW (1999) Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. Arch Gen Psychiatry 56:1001–1005PubMedCrossRefGoogle Scholar
  13. Light GA, Hsu JL, Hsieh MH, Meyer-Gomes K, Sprock J, Swerdlow NR, Braff DL (2006) Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients. Biol Psychiatry 60:1231–1240PubMedCrossRefGoogle Scholar
  14. Linden RD, Campbell KB, Hamel G, Picton TW (1985) Human auditory steady state evoked potentials during sleep. Ear Hear 6:167–174PubMedCrossRefGoogle Scholar
  15. Linden RD, Picton TW, Hamel G, Campbell KB (1987) Human auditory steady-state evoked potentials during selective attention. Electroencephalogr Clin Neurophysiol 66:145–159PubMedCrossRefGoogle Scholar
  16. Makela JP, Hari R (1987) Evidence for cortical origin of the 40 Hz auditory evoked response in man. Electroencephalogr Clin Neurophysiol 66:539–546PubMedCrossRefGoogle Scholar
  17. Morup M, Hansen LK, Herrmann CS, Parnas J, Arnfred SM (2006) Parallel factor analysis as an exploratory tool for wavelet transformed event-related EEG. Neuroimage 29:938–947PubMedCrossRefGoogle Scholar
  18. Morup M, Hansen LK, Arnfred SM (2007) ERPWAVELAB A toolbox for multi-channel analysis of time-frequency transformed event related potentials. J Neurosci Methods 161:361–368PubMedCrossRefGoogle Scholar
  19. Oken BS, Salinsky MC, Elsas SM (2006) Vigilance, alertness, or sustained attention: physiological basis and measurement. Clin Neurophysiol 117:1885–1901PubMedCrossRefGoogle Scholar
  20. Osipova D, Pekkonen E, Ahveninen J (2006) Enhanced magnetic auditory steady-state response in early Alzheimer’s disease. Clin Neurophysiol 117:1990–1995PubMedCrossRefGoogle Scholar
  21. Pantev C, Roberts LE, Elbert T, Ross B, Wienbruch C (1996) Tonotopic organization of the sources of human auditory steady-state responses. Hear Res 101:62–74PubMedCrossRefGoogle Scholar
  22. Pastor MA, Thut G, Pascual-Leone A (2006) Modulation of steady-state auditory evoked potentials by cerebellar rTMS. Exp Brain Res 175:702–709PubMedCrossRefGoogle Scholar
  23. Picton TW, John MS, Dimitrijevic A, Purcell D (2003a) Human auditory steady-state responses. Int J Audiol 42:177–219PubMedCrossRefGoogle Scholar
  24. Picton TW, John MS, Purcell DW, Plourde G (2003b) Human auditory steady-state responses: the effects of recording technique and state of arousal. Anesth Analg 97:1396–1402PubMedCrossRefGoogle Scholar
  25. Pockett S, Tan SM (2002) The auditory steady-state response is not a suitable monitor of anesthesia. Anesth Analg 95:1318–1323, table of contentsPubMedCrossRefGoogle Scholar
  26. Regan D (1989) Human brain electrophysiology: evoked potentials and evoked magnetic fields in science and medicine. Elsevier, New YorkGoogle Scholar
  27. Ross B, Picton TW, Herdman AT, Pantev C (2004) The effect of attention on the auditory steady-state response. Neurol Clin Neurophysiol 2004:22PubMedGoogle Scholar
  28. Venables P (1984) Arousal: an examination of its status as a concept. In: Stern JA (ed) Psychophysiological perspectives—festschrift for Beatrice and John Lacey. Van Nostrand Reinhold, New York, pp 134–142Google Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Inga Griskova
    • 1
    • 2
    • 3
  • Morten Morup
    • 4
  • Josef Parnas
    • 1
  • Osvaldas Ruksenas
    • 2
  • Sidse M. Arnfred
    • 1
  1. 1.Department of PsychiatryHvidovre Hospital, University Hospital of CopenhagenCopenhagenDenmark
  2. 2.Department of Biochemistry and BiophysicsVilnius UniversityVilniusLithuania
  3. 3.Department of Electrophysiological Treatment and Investigation MethodsVilnius Republican Psychiatric HospitalVilniusLithuania
  4. 4.Informatics and Mathematical ModelingTechnical University of DenmarkLyngbyDenmark

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