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Experimental Brain Research

, Volume 182, Issue 3, pp 357–364 | Cite as

Enhanced cognitive control in Tourette Syndrome during task uncertainty

  • G. M. Jackson
  • S. C. Mueller
  • K. Hambleton
  • C. P. Hollis
Research Article

Abstract

Tourette Syndrome (TS) is a developmental neurological condition that is characterised by the presence of multiple motor and one or more vocal tics. Tics are highly stereotyped repetitive behaviours that fluctuate in type, complexity and severity. TS has been linked to impaired cognitive control processes, however, a recent study (Mueller et al. in Curr Biol 16:570–573, 2006) demonstrated that young people with TS, although exhibiting chronic motor and vocal tics, nevertheless performed significantly better than a group of age-matched controls on a task that required extremely high levels of cognitive control (i.e., predictably shifting between executing pro-saccade and anti-saccade responses to a visual stimulus). As predictable task sequences allow task-related cognitive processes to commence prior to the presentation of target stimuli we examined whether the superior performance of the TS group could be replicated when task sequences were varied unpredictably. Our results confirmed that both the TS group and an age-matched control group benefited, by the same extent, when the saccade task (pro-saccade vs. anti-saccade) was pre-cued. In contrast, while the control group showed a significant decrease in performance on task switch trials relative to task repetition trials—the TS group exhibited no significant ‘costs’ of switching task. While task performance was modulated by response and target location shifts in the control group, these factors had less impact on the TS group’s performance on task switch trials. These results confirm and extend the previous demonstration that individuals with TS exhibit paradoxically greater levels of cognitive control than healthy controls.

Keywords

Cognitive control Tourette syndrome Eye movements Executive function 

References

  1. Albin RL, Mink JW (2006) Recent advances in Tourette Syndrome research. Trends Neurosci 29:175–182PubMedCrossRefGoogle Scholar
  2. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381PubMedCrossRefGoogle Scholar
  3. Banaschewski T, Woerner W, Rothenberger A (2003) Premonitory sensory phenomena and suppressibility of tics in Tourette syndrome: developmental aspects in children and adolescents. Dev Med Child Neurol 45(10):700–703PubMedCrossRefGoogle Scholar
  4. Barton JJS, Greenzang C, Hefter R, Edelman J, Manoach DS (2006) Switching, plasticity, and prediction in a saccadic task-switch paradigm. Exp Brain Res 168:76–87PubMedCrossRefGoogle Scholar
  5. Bialystok E, Senman L (2004) Executive processes in appearance-reality tasks: the role of inhibition of attention and symbolic representation. Child Dev 75:562–579PubMedCrossRefGoogle Scholar
  6. Fecteau JH, Armstrong IT, Munoz DP (2004) Sensory biases produce alternation advantage found in sequential saccadic eye movement tasks. Exp Brain Res 159:84–91PubMedGoogle Scholar
  7. Georgiou N, Bradshaw JL, Phillips JG, Bradshaw JA, Chiu E (1995) The Simon effect and attention deficits in Gilles de la Tourette’s Syndrome and Huntington’s disease. Brain 118:1305–1318PubMedCrossRefGoogle Scholar
  8. Goodman R (2001) Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry 40:1337–1345PubMedCrossRefGoogle Scholar
  9. Hays JR, Reas DL, Shaw JB (2002) Concurrent validity of the Wechsler abbreviated scale of intelligence and the Kaufman brief intelligence test among psychiatric inpatients. Psychol Rep 90:355–359PubMedCrossRefGoogle Scholar
  10. Jackson GM (2006) Tourette’s Syndrome. Curr Biol 16:443–444CrossRefGoogle Scholar
  11. Koch I (2005) Sequential task predictability in task switching. Psychon Bull Rev 12:107–112PubMedGoogle Scholar
  12. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28:566–573PubMedCrossRefGoogle Scholar
  13. Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y-S, Peterson BS (1998) Course of tic severity in Tourette Syndrome: the first two decades. Pediatrics 102:14–19PubMedCrossRefGoogle Scholar
  14. Leckman JF, Vaccarino FM, Kalanithi PS, Rothenberger A (2006) Annotation: Tourette Syndrome: a relentless drumbeat—driven by misguided brain oscillations. J Child Psychol Psychiatry 47:537–550PubMedCrossRefGoogle Scholar
  15. Mink JW (1996) The basal ganglia: focused selection and inhibition of competing motor programs. Progr Neurobiol 50:381–425CrossRefGoogle Scholar
  16. Monsell S (2003) Task switching. Trends Cogn Sci 7:134–140PubMedCrossRefGoogle Scholar
  17. Mostofsky SH, Lasker AG, Singer HS, Denckla MB, Zee DS (2001) Oculomotor abnormalities in boys with Tourette Syndrome with and without ADHD. J Am Acad Child Adolesc Psychiatry 40:1464–1472PubMedCrossRefGoogle Scholar
  18. Mueller SC (2006) Contributions of task and response-level factors to the asymmetrical switch cost. Unpublished doctoral dissertation. School of Psychology, University of Nottingham, NottinghamGoogle Scholar
  19. Mueller SC, Jackson GM, Dhalla R, Datsopoulos S, Hollis CP (2006) Enhanced cognitive control in young people with Tourette’s Syndrome. Curr Biol 16:570–573PubMedCrossRefGoogle Scholar
  20. Muris P, Meesters C, van den Berg F (2003) The strength and difficulties questionnaire (SDQ)—further evidence for its reliability and validity in a community sample of Dutch children and adolescents. Eur Child Adolesc Psychiatry 12:1–8PubMedCrossRefGoogle Scholar
  21. Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC (1998) A functional magnetic resonance imaging study of tic suppression in Tourette Syndrome. Arch Gen Psychiatry 55:326–333PubMedCrossRefGoogle Scholar
  22. Rafal R, Egly R, Rhodes D (1994) Effects of inhibition of return on voluntary and visually guided saccades. Can J Exp Psychol 48:284–300PubMedCrossRefGoogle Scholar
  23. Redgrave P, Prescott TJ, Gurney K (1999) The basal ganglia: a vertebrate solution to the selection problem? Neuroscience 89:1009–1023PubMedCrossRefGoogle Scholar
  24. Reulen JPH, Marcus JT, Koops D, de Vries FR, Tiesinga G, Boshuizen K, Bos JE (1988) Precise recording of eye movement: the IRIS technique Part 1. Med Biol Eng Comput 26:20–26PubMedCrossRefGoogle Scholar
  25. Reuter B, Philipp AM, Koch I, Kathmann N (2006) Effects of switching between leftward and rightward pro- and antisaccades. Biol Psychol 72:88–95PubMedCrossRefGoogle Scholar
  26. Serrien DJ, Orth M, Evans AH, Lees AJ, Brown P (2005) Motor inhibition in patients with Gilles de la Tourette Syndrome: functional activation patterns as revealed by EEG coherence. Brain 128:116–125PubMedCrossRefGoogle Scholar
  27. Swainson R, Jackson SR, Jackson GM (2006) Using advance information in dynamic cognitive control: an ERP study of task-switching. Brain Res 1105:61–72PubMedCrossRefGoogle Scholar
  28. Walkup TJ, Rosenberg LA, Brown J, Singer HS (1992) The validity of instruments measuring tic severity in Tourette’s Syndrome. J Am Acad Child Adolesc Psychiatry 31:472–477PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • G. M. Jackson
    • 1
  • S. C. Mueller
    • 1
  • K. Hambleton
    • 1
  • C. P. Hollis
    • 1
  1. 1.Division of Psychiatry, Queen’s Medical CentreThe University of NottinghamNottinghamUK

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