Experimental Brain Research

, Volume 179, Issue 4, pp 655–664 | Cite as

Placebo analgesia: a PET study

  • Hidenori Nemoto
  • Yuki Nemoto
  • Hikaru Toda
  • Masahiko Mikuni
  • Hidenao Fukuyama
Research Article


Placebo analgesia involves complex mechanisms and sometimes has a marked effect on patients in pain. In this study we examined changes in regional cerebral blood flow (rCBF) under three different conditions (resting, hot, painful) before and after placebo administration using H 2 15 O and positron emission tomography in ten healthy subjects. In five subjects, placebo administration significantly decreased pain-intensity score (placebo responders), and rCBF in the medial prefrontal cortex (MPFC), posterior parietal cortex (PPC), and inferior parietal lobe (IPL) increased after placebo administration compared with before placebo administration under the painful condition. Furthermore, in the placebo responders, rCBF in the MPFC, PPC and IPL also increased under the resting condition (without sensory stimulation) after placebo administration compared with before placebo administration. However, there was no rCBF change under the rest condition in the placebo nonresponders after placebo administration. These results suggest that placebo analgesia has its effect under the resting condition and MPFC, IPL and PPC may have an important role in placebo analgesia.


Placebo analgesia Positron emission tomography Regional cerebral blood flow Psychological effect 



We would like to thank Mr. Kunio Matsubara, Division of Radiology, Gunma University Hospital, for supporting this project. This study was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This study was carried out at Gunma University Hospital.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Hidenori Nemoto
    • 1
  • Yuki Nemoto
    • 1
  • Hikaru Toda
    • 2
  • Masahiko Mikuni
    • 3
  • Hidenao Fukuyama
    • 4
  1. 1.Department of AnesthesiologyMito Red Cross HospitalMitoJapan
  2. 2.Department of AnesthesiologySaitama Cancer CenterKitaadachi-gunJapan
  3. 3.Department of Neuropsychiatry and Human BehaviorGunma UniversityMaebashiJapan
  4. 4.Human Brain Research CenterKyoto University Graduate School of MedicineKyotoJapan

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