Experimental Brain Research

, Volume 175, Issue 4, pp 575–583 | Cite as

Reduced functional activation after fatiguing exercise is not confined to primary motor areas

  • Nicola M. Benwell
  • Frank L. Mastaglia
  • Gary W. Thickbroom
Research Article


We have previously shown that following a period of unimanual fatiguing exercise, there is a reduction in primary sensorimotor cortex (SM1) activation with movement of either the fatigued or the non-fatigued hand by Benwell et al. (Exp Brain Res 167:160–164, 2005). In the present study we have investigated whether this reduction is confined to motor areas or is more widespread. Functional imaging was performed before and after a 10-minute fatiguing exercise of the left hand (30% of maximum handgrip strength) in seven normal subjects (4 M, mean age 25 years). The activating task was a handgrip against a low resistance (1 kg) in response to a visual cue (chequerboard reversal every 2 ± 0.5 s). We compared activation in SM1, supplementary motor area (SMA), cerebellum (CB) and primary visual cortex (V1) before and after the fatiguing exercise. After exercise, contralateral SM1 activation was reduced by 33% (< 0.05) compared to baseline for the fatigued hand and by 49% for the non-fatigued hand (< 0.05). A similar pattern was seen for the bilateral SMA and ipsilateral CB following exercise (45 vs. 50% for SMA; 30 vs. 35% for CB; fatigued versus non-fatigued). Activation was also reduced in V1 but to a lesser extent than in motor areas (19 vs. 24%; fatigued versus non-fatigued). These results show that although the reduced functional activation during the recovery period after fatiguing exercise is more marked in motor areas, it also extends to non-motor areas such as the visual cortex, suggesting that there are more widespread changes in cerebral haemodynamic responses after fatigue.


Functional imaging Fatigue Cerebral haemodynamics 


  1. Bandettini PA, Kwong KK, Davis TL, Tootell RB, Wong EC, Fox PT, Belliveau JW, Weisskoff RM, Rosen BR (1997) Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation. Hum Brain Mapp 5:93–109PubMedCrossRefGoogle Scholar
  2. Benwell NM, Byrnes ML, Mastaglia FL, Thickbroom GW (2005) Primary sensorimotor cortex activation with task-performance after fatiguing hand exercise. Exp Brain Res 167:160–164PubMedCrossRefGoogle Scholar
  3. Benwell NM, Sacco P, Hammond GR, Byrnes ML, Mastaglia FL, Thickbroom GW (2006) Short-interval cortical inhibition and corticomotor excitability with fatiguing hand exercise: a central adaptation to fatigue? Exp Brain Res 170:191–198PubMedCrossRefGoogle Scholar
  4. Bonato C, Zanette G, Manganotti P, Tinazzi M, Bongiovanni G, Polo A, Fiaschi A (1996) ‘Direct’ and ‘crossed’ modulation of human motor cortex excitability following exercise. Neurosci Lett 216:97–100PubMedGoogle Scholar
  5. Brasil-Neto JP, Pascual-Leone A, Valls-Sole J, Cammarota A, Cohen LG, Hallett M (1993) Postexercise depression of motor evoked potentials: a measure of central nervous system fatigue. Exp Brain Res 93:181–184PubMedCrossRefGoogle Scholar
  6. Dalsgaard MK, Volianitis S, Yoshiga CC, Dawson EA, Secher NH (2004) Cerebral metabolism during upper and lower body exercise. J Appl Physiol 97:1733–1739PubMedCrossRefGoogle Scholar
  7. Humphry AT, Lloyd-Davies EJ, Teare RJ, Williams KE, Strutton PH, Davey NJ (2004) Specificity and functional impact of post-exercise depression of cortically evoked motor potentials in man. Eur J Appl Physiol 92:211–218PubMedCrossRefGoogle Scholar
  8. Ide K, Schmalbruch IK, Quistorff B, Horn A, Secher NH (2000) Lactate, glucose and O2 uptake in human brain during recovery from maximal exercise. J Physiol 522(Pt 1):159–164PubMedCrossRefGoogle Scholar
  9. Jancke L, Peters M, Schlaug G, Posse S, Steinmetz H, Muller-Gartner H (1998) Differential magnetic resonance signal change in human sensorimotor cortex to finger movements of different rate of the dominant and subdominant hand. Brain Res Cogn Brain Res 6:279–284PubMedCrossRefGoogle Scholar
  10. Lazarski JP, Ridding MC, Miles TS (2002) Dexterity is not affected by fatigue-induced depression of human motor cortex excitability. Neurosci Lett 321:69–72PubMedCrossRefGoogle Scholar
  11. Liu JZ, Dai TH, Sahgal V, Brown RW, Yue GH (2002) Nonlinear cortical modulation of muscle fatigue: a functional MRI study. Brain Res 957:320–329PubMedCrossRefGoogle Scholar
  12. Liu JZ, Shan ZY, Zhang LD, Sahgal V, Brown RW, Yue GH (2003) Human brain activation during sustained and intermittent submaximal fatigue muscle contractions: an FMRI study. J Neurophysiol 90:300–312PubMedCrossRefGoogle Scholar
  13. Sacco P, Thickbroom GW, Thompson ML, Mastaglia FL (1997) Changes in corticomotor excitation and inhibition during prolonged sub-maximal muscle contractions. Muscle Nerve 20:1158–1166PubMedCrossRefGoogle Scholar
  14. Sacco P, Thickbroom GW, Byrnes ML, Mastaglia FL (2000) Changes in corticomotor excitability after fatiguing muscle contractions. Muscle Nerve 23:1840–1846PubMedCrossRefGoogle Scholar
  15. Taylor JL, Butler JE, Allen GM, Gandevia SC (1996) Changes in motor cortical excitability during human muscle fatigue. J Physiol (Lond) 490:519–528Google Scholar
  16. Thickbroom GW, Byrnes ML, Mastaglia FL (2003) Dual representation of the hand in the cerebellum: activation with voluntary and passive finger movement. Neuroimage 18:670–674PubMedCrossRefGoogle Scholar
  17. Thickbroom GW, Phillips BA, Morris I, Byrnes ML, Sacco P, Mastaglia FL (1999) Differences in functional magnetic resonance imaging of sensorimotor cortex during static and dynamic finger flexion. Exp Brain Res 126:431–438PubMedCrossRefGoogle Scholar
  18. Waldvogel D, van Gelderen P, Muellbacher W, Ziemann U, Immisch I, Hallett M (2000) The relative metabolic demand of inhibition and excitation. Nature 406:995–998PubMedCrossRefGoogle Scholar
  19. Wu T, Kansaku K, Hallett M (2004) How self-initiated memorized movements become automatic: a functional MRI study. J Neurophysiol 91:1690–1698PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Nicola M. Benwell
    • 1
  • Frank L. Mastaglia
    • 1
  • Gary W. Thickbroom
    • 1
  1. 1.Centre for Neuromuscular and Neurological DisordersUniversity of Western Australia, Queen Elizabeth II Medical CentreNedlandsAustralia

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