Experimental Brain Research

, Volume 162, Issue 2, pp 257–264

Excitotoxic lesions of the pedunculopontine tegmental nucleus in rats impair performance on a test of sustained attention

  • Rouba Kozak
  • Eric M. Bowman
  • Mary P. Latimer
  • Claire L. Rostron
  • Philip Winn
Research Article

Abstract

Recent research has suggested that the pontomesencephalic tegmentum might be an important part of a network underlying sustained attention. The largest structure of the pontomesencephalic tegmentum is the pedunculopontine tegmental nucleus, which has ascending connections to thalamus and with corticostriatal systems. In this experiment we examined the performance of rats following bilateral excitotoxic lesions of the pedunculopontine tegmental nucleus on a test of sustained attention previously used to examine frontal cortical function. After an initial period of darkness, the rats had to attend continuously to a dim stimulus light that would, at unpredictable intervals, become transiently brighter. During this period of increased stimulus brightness the rats could press a lever to obtain a food reward. Rats were trained to a criterion level of performance before lesions were made. After surgery, sham lesioned rats (n=7) resumed accurate responding, with an average successful detection rate of ~70%. Pedunculopontine lesioned rats (n=7), however, only achieved a successful detection rate of ~40%. When the duration of the bright target stimulus was increased from 1.5 to 4 s, the performance of the pedunculopontine lesioned rats significantly improved. The observation that an increase in brightness duration caused a marked improvement in lesioned rats’ performance suggests strongly that the impairment was in attention rather than motor ability or simple sensory processing. These data are taken to be consistent with the hypothesis that the pedunculopontine tegmental nucleus is an important part of a network maintaining attention.

Keywords

Acetylcholine Ascending reticular activating system Basal forebrain Corticostriatal Executive function Pontomesencephalic tegmentum Thalamus 

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Rouba Kozak
    • 2
  • Eric M. Bowman
    • 1
  • Mary P. Latimer
    • 1
  • Claire L. Rostron
    • 1
  • Philip Winn
    • 1
  1. 1.School of PsychologyUniversity of St AndrewsSt AndrewsScotland
  2. 2.Department of PsychologyOhio State UniversityColumbusUSA

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