Experimental Brain Research

, Volume 159, Issue 2, pp 263–267 | Cite as

Verbal instructions and top-down saccade control

  • U. P. Mosimann
  • J. Felblinger
  • S. J. Colloby
  • R. M. Müri
Research Note


Few studies have addressed the interaction between instruction content and saccadic eye movement control. To assess the impact of instructions on top-down control, we instructed 20 healthy volunteers to deliberately delay saccade triggering, to make inaccurate saccades or to redirect saccades—i.e. to glimpse towards and then immediately opposite to the target. Regular pro- and antisaccade tasks were used for comparison. Bottom-up visual input remained unchanged and was a gap paradigm for all instructions. In the inaccuracy and delay tasks, both latencies and accuracies were detrimentally impaired by either type of instruction and the variability of latency and accuracy was increased. The intersaccadic interval (ISI) required to correct erroneous antisaccades was shorter than the ISI for instructed direction changes in the redirection task. The word-by-word instruction content interferes with top-down saccade control. Top-down control is a time consuming process, which may override bottom-up processing only during a limited time period. It is questionable whether parallel processing is possible in top-down control, since the long ISI for instructed direction changes suggests sequential planning.


Instruction Saccade Antisaccade Top-down control Bottom-up control 


  1. Becker W, Jurgens R (1979) An analysis of the saccadic system by means of double step stimuli. Vision Res 19:967–983CrossRefPubMedGoogle Scholar
  2. Everling S, Fischer B (1998) The antisaccade: a review of basic research and clinical studies. Neuropsychologia 36:885–899CrossRefPubMedGoogle Scholar
  3. Findlay JM, Walker R (1999) A model of saccade generation based on parallel processing and competitive inhibition. Behav Brain Sci 22:661–674; discussion 674–721CrossRefPubMedGoogle Scholar
  4. Fischer B, Weber H (1992) Characteristics of “anti” saccades in man. Exp Brain Res 89:415–424CrossRefPubMedGoogle Scholar
  5. Fischer B, Weber H, Biscaldi M, Aiple F, Otto P, Stuhr V (1993) Separate populations of visually guided saccades in humans: reaction times and amplitudes. Exp Brain Res 92:528–541CrossRefPubMedGoogle Scholar
  6. Hallett PE (1978) Primary and secondary saccades to goals defined by instructions. Vision Res 18:1279–1296CrossRefPubMedGoogle Scholar
  7. Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 80:953–978PubMedGoogle Scholar
  8. Inhoff AW (1986) Preparing sequences of saccades under choice reaction conditions: effects of sequence length and context. Acta Psychol (Amst) 61:211–228Google Scholar
  9. Kowler E, Blaser E (1995) The accuracy and precision of saccades to small and large targets. Vision Res 35:1741–1754CrossRefPubMedGoogle Scholar
  10. Leigh RJ, Kennard C (2004) Using saccades as a research tool in the clinical neurosciences. Brain 127:460–477CrossRefPubMedGoogle Scholar
  11. Mokler A, Fischer B (1999) The recognition and correction of involuntary prosaccades in an antisaccade task. Exp Brain Res 125:511–516CrossRefPubMedGoogle Scholar
  12. Munoz DP, Dorris MC, Pare M, Everling S (2000) On your mark, get set: brainstem circuitry underlying saccadic initiation. Can J Physiol Pharmacol 78:934–944CrossRefPubMedGoogle Scholar
  13. Pierrot-Deseilligny C, Muri RM, Ploner CJ, Gaymard B, Demeret S, Rivaud-Pechoux S (2003a) Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour. Brain 126:1460–1473CrossRefPubMedGoogle Scholar
  14. Pierrot-Deseilligny C, Muri RM, Ploner CJ, Gaymard B, Rivaud-Pechoux S (2003b) Cortical control of ocular saccades in humans: a model for motricity. Prog Brain Res 142:3–17PubMedGoogle Scholar
  15. Turner M (1997) Malingering. Br J Psychiatry 171:409–411PubMedGoogle Scholar
  16. Zingale CM, Kowler E (1987) Planning sequences of saccades. Vision Res 27:1327–1341Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • U. P. Mosimann
    • 1
    • 2
  • J. Felblinger
    • 1
    • 3
  • S. J. Colloby
    • 2
  • R. M. Müri
    • 1
  1. 1.Perception and Eye Movement Laboratory, Departments of Neurology and Clinical ResearchUniversity of BernBernSwitzerland
  2. 2.Institute for Ageing and HealthNewcastle General HospitalNewcastle upon TyneUK
  3. 3.Department of RadiologyUniversity of NancyNancyFrance

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