Experimental Brain Research

, Volume 161, Issue 1, pp 81–90 | Cite as

Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) “Go, No-Go” study

  • Jillian A. Toogood
  • Amy M. Barr
  • Todd K. Stevens
  • Joseph S. Gati
  • Ravi S. Menon
  • Ruth E. Martin
Research Article

Abstract

Brain-imaging studies have shown that visually-cued, voluntary swallowing activates a distributed network of cortical regions including the precentral and postcentral gyri, anterior cingulate cortex (ACC), insula, frontoparietal operculum, cuneus and precuneus. To elucidate the functional contributions of these discrete activation foci for swallowing, a “Go, No-Go” functional magnetic resonance imaging (fMRI) paradigm was designed. Brain activation associated with visually-cued swallowing was compared with brain activation evoked by a comparable visual cue instructing the subject not to swallow. Region-of-interest analyses performed on data from eight healthy subjects showed a significantly greater number of activated voxels within the precentral gyrus, postcentral gyrus, and ACC during the “Go” condition compared to the “No-Go” condition. This finding suggests that the precentral gyrus, postcentral gyrus, and ACC contribute primarily to the act of swallowing. In contrast, the numbers of activated voxels within the cuneus and precuneus were not significantly different for the “Go” and “No-Go” conditions, suggesting that these regions mediate processing of the cue to swallow. Together these findings support the view that the discrete cortical foci previously implicated in swallowing mediate functionally distinct components of the swallowing act.

Keywords

Deglutition Brain-imaging Functional neuroanatomy Neurophysiology 

Notes

Acknowledgements

This research was supported by a Ontario Ministry Health Career Scientist Award to REM, a Natural Sciences and Engineering Research Council (NSERC) grant (REM), a Canada Research Chair Support to RSM, and a CIHR Maintenance grant (RSM). The authors acknowledge the valuable contributions of Dr. Christopher Thomas in computer programming and data analysis.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Jillian A. Toogood
    • 1
    • 2
  • Amy M. Barr
    • 2
  • Todd K. Stevens
    • 5
    • 7
  • Joseph S. Gati
    • 7
  • Ravi S. Menon
    • 1
    • 4
    • 5
    • 6
    • 7
  • Ruth E. Martin
    • 1
    • 3
    • 4
  1. 1.Graduate Program in NeuroscienceUniversity of Western OntarioLondonCanada
  2. 2.School of Communication Sciences and Disorders, Faculty of Health SciencesUniversity of Western OntarioLondonCanada
  3. 3.Faculty of Health Sciences, Elborn College, Room 2568University of Western OntarioLondonCanada
  4. 4.Department of Physiology and PharmacologyUniversity of Western OntarioLondonCanada
  5. 5.Department of Medical BiophysicsUniversity of Western OntarioLondonCanada
  6. 6.Department of Diagnostic Radiology and Nuclear MedicineUniversity of Western OntarioLondonCanada
  7. 7.Laboratory for Functional Magnetic Resonance ResearchRobarts Research InstituteLondonCanada

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