Experimental Brain Research

, Volume 156, Issue 1, pp 11–19 | Cite as

Modulation of interhemispheric inhibition during passive movement of the upper limb reflects changes in motor cortical excitability

Research Article
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Abstract

We investigated modulation of inhibition of motor evoked potentials in the left forearm musculature attributable to changes in corticomotor excitability induced by passive rhythmic movement of the right limb. In the first experiment, eight healthy volunteers pre-activated their left flexor carpi radialis (FCR) in a simple isometric contraction (2.5–7.5% MVC) while their right hand underwent passive wrist flexion-extension. Transcranial magnetic (TMS) or electrical (TES) stimulation was applied to the right motor cortex and responses recorded from the test (left) limb in eight phases of the wrist flexion-extension cycle of the passively driven right limb. In half of the trials TMS conditioning was applied to the left motor cortex. The conditioning stimulus significantly inhibited TMS-evoked responses in the test FCR muscle, whereas TES-evoked responses did not appear to be inhibited. For TMS-evoked responses only, inhibition in the static pre-activated left FCR was modulated such that inhibition was greater when the right wrist was passively flexing than when it was extending. In the second experiment TMS was applied to the right motor cortex, contralateral to the test (left) limb, with the right hand either passively extending or flexing through the neutral position. Conditioning was applied to the left motor cortex at a range of intensities adjusted to threshold for flexion and extension movements. No difference was evident in the maximum magnitude of inhibition between the extension and flexion conditions. We propose there is an increased absolute threshold for recruitment and a decreased gain of inhibitory callosal pathways during extension phases of the wrist flexion-extension cycle.

Keywords

Interhemispheric inhibition (IHI) Motor evoked potential (MEP) Corpus callosum Human Upper limb 
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Notes

Acknowledgements

The authors would like to thank Gwyn Lewis, Steve McMillan, Vanessa Lim, and Melody Polych for assistance with data collection, and Richard Carson, Gwyn Lewis and Jim Stinear, and two anonymous reviewers for helpful comments on this manuscript. S.W. was supported by a Faculty of Science Study Award, University of Auckland and a Sport and Exercise Science Departmental Scholarship, University of Auckland. This research was supported by a Staff Research Grant to W.B.

References

  1. Carroll TJ, Riek S, Carson RG (2001) Reliability of the input-output properties of the cortico-spinal pathway obtained from transcranial magnetic and electrical stimulation. J Neurosci Methods 112:193–202PubMedGoogle Scholar
  2. Carson RG, Byblow WD, Riek S, Lewis GN, Stinear JW (2000) Passive movement alters the transmission of corticospinal input to upper limb motoneurones. Abstracts for 30th Annual Meeting of Society for Neuroscience 1231Google Scholar
  3. Chen R (2000) Studies of human motor physiology with transcranial magnetic stimulation. Muscle Nerve [Supp 9]: S26–S32Google Scholar
  4. Day BL, Dressler D, Maertens De Noordhout A, Marsden CD, Nakashima K, Rothwell JC, Thompson PD (1989) Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses. J Physiol 412:449–473PubMedGoogle Scholar
  5. Devanne H, Lavoie BA, Capaday C (1997) Input-output properties and gain changes in the human corticospinal pathway. Exp Brain Res 114:329–338PubMedGoogle Scholar
  6. Devanne H, Cohen L, Kouchtir-Devanne N, Capaday C (2001) Integrated motor cortical control of task-related muscles during pointing in humans. J Neurophysiol 87:3006–3017Google Scholar
  7. Di Lazzaro V, Oliviero A, Profice P, Insola A, Mazzone P, Tonali P, Rothwell JC (1999) Direct demonstration of interhemispheric inhibition of the human motor cortex produced by transcranial magnetic stimulation. Exp Brain Res 124:520–524PubMedGoogle Scholar
  8. Eliassen JC, Baynes K, Gazzaniga MS (1999) Direction information coordinated via the posterior third of the corpus callosum during bimanual movements. Exp Brain Res 128:573–577PubMedGoogle Scholar
  9. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD (1992) Interhemispheric inhibition of the human motor cortex. J Physiol 453:525–546PubMedGoogle Scholar
  10. Gazzaniga MS (2000) Cerebral specialization and interhemispheric communication: does the corpus callosum enable the human condition? Brain 123:1293–1326CrossRefPubMedGoogle Scholar
  11. Gerloff C, Cohen LG, Floeter MK, Chen R, Corwell B, Hallett M (1998) Inhibitory influence of the ipsilateral motor cortex on responses to stimulation of the human cortex and pyramidal tract. J Physiol 510:249–259PubMedGoogle Scholar
  12. Hanajima R, Ugawa Y, Machii K, Mochizuki H, Terao Y, Enomoto H, Furubayashi T, Shiio Y, Uesugi H, Kanazawa I (2001) Interhemispheric facilitation of the hand motor area in humans. J Physiol 531:849–859PubMedGoogle Scholar
  13. Jenny AB (1979) Commisural projections of the cortical hand motor area in monkeys. J Comp Neurol 188:137–146PubMedGoogle Scholar
  14. Jones EG, Coulter JD, Wise SP (1979) Commisural columns in the sensory-motor cortex of monkeys. J Comp Neurol 188:113–136PubMedGoogle Scholar
  15. Lewis GN, Byblow WD (2002) Modulations in corticomotor excitability during passive limb movement. Is there a cortical influence? Brain Res 943:263–275CrossRefPubMedGoogle Scholar
  16. Lewis GN, Byblow WD, Carson RG (2001) Phasic modulation of corticomotor excitability during passive movement of the upper limb: effects of movement frequency and muscle specificity. Brain Res 900:282–294PubMedGoogle Scholar
  17. Meyer BU, Roricht S (1996) Callosally and corticospinally mediated motor responses induced by transcranial magnetic stimulation in man originate from the same motor cortex region. J Physiol 491P:119Google Scholar
  18. Meyer BU, Roricht S, Grafin von Einsiedel H, Kruggel F, Weindl A (1995) Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 118:429–440PubMedGoogle Scholar
  19. Meyer BU, Roricht S, Woiciechowsky C (1998) Topography of fibers in the human corpus callosum mediating interhemispheric inhibition between the motor cortices. Ann Neurol 43:360–369PubMedGoogle Scholar
  20. Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113PubMedGoogle Scholar
  21. Preilowski B (1972) Possible contribution of the anterior forebrain commisures to bilateral motor coordination. Neuropsychologia 10:267–277PubMedGoogle Scholar
  22. Reddy H, Lassonde M, Bemasconi A, Matthews PM, Andermann F, Amold DL (2000) An fMRI study of the lateralization of motor cortex activation in acallosal patients. Neuroreport 11:2409–2413PubMedGoogle Scholar
  23. Rothwell JC, Colebatch J, Britton TC, Priori A, Thompson PD, Day BL, Marsden CD (1991) Physiological studies in a patient with mirror movements and agenesis of the corpus callosum. J Physiol 438:34PGoogle Scholar
  24. Salerno A, Georgesco M (1996) Interhemispheric facilitation and inhibition studied in man with double magnetic stimulation. Electroencephalograph Clin Neurophysiol 101:395–403Google Scholar
  25. Schnitzler A, Kessler KR, Benecke R (1996) Transcallosally mediated inhibition of interneurons within human primary motor cortex. Exp Brain Res 112:381–391PubMedGoogle Scholar
  26. Stein RB (1995) Presynaptic inhibition in humans. Prog Neurobiol 47:533–544PubMedGoogle Scholar
  27. Ugawa Y, Hanajima R, Kanazawa I (1993) Interhemispheric facilitation of the hand area of the human motor cortex. Neurosci Lett 160:153–155PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Human Motor Control Laboratorym University of Auckland—Tamaki CampusAucklandNew Zealand

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