European Food Research and Technology

, Volume 245, Issue 1, pp 225–232 | Cite as

Evaluation of chemical species and bioaccessibility of selenium in dietary supplements

  • Zhenying Hu
  • Ayako Shiokawa
  • Noriyuki Suzuki
  • Hua Xiong
  • Yasumitsu OgraEmail author
Original Paper


Many kinds of selenium (Se)-enriched supplements are commercially available. To ensure appropriate Se intake, the amount of Se and its chemical species should appear on the bottle or package label. In this study, we verified the Se species and evaluated their potential bioavailability in four commercial Se supplements. The total amounts of Se in all the samples almost coincided with the values indicated on the labels. A hyphenated technique consisting of HPLC and inductively coupled plasma mass spectrometry was used for the speciation of Se in the samples. Although one sample had indicated selenomethionine on its label, it was found to contain solely selenate. Other samples that had selenized yeast (Se-yeast) on their labels mainly contained Se-containing proteins and/or peptides. One Se-yeast sample showed low bioaccessibility (59.71%), in contrast to the two other samples that had around 100% bioaccessibility. The Se supplements actually contained the labeled amount of Se, although some did not contain the Se species indicated on the label and thus were expected to have less Se nutritional availability due to the low bioaccessibility.


Supplement Selenium Speciation Bioaccessibility LC–ICP–MS 



This study was supported by Grants from JSPS KAKENHI (Grant Numbers 16H05812, 17H04001, 18H03380, and 18K19387).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Compliance with ethics requirements

This article does not contain any studies with human or animal subjects.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Food Science and TechnologyNanchang UniversityNanchangChina
  2. 2.Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan

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