European Food Research and Technology

, Volume 227, Issue 1, pp 167–174 | Cite as

Preparation of salidroside nano-liposomes by ethanol injection method and in vitro release study

  • Minghui Fan
  • Shiying Xu
  • Shuqin Xia
  • Xiaoming Zhang
Original Paper


The purpose of this work was to prepare salidroside nano-liposomes by the ethanol injection method. To obtain the higher encapsulating efficiency of salidroside nano-liposomes, several factors including salidroside-loading capacity, cholesterol, Tween 80, ion strength and lipid concentration were investigated. The higher encapsulating efficiency of salidroside, 45%, was obtained with cholesterol to lipid mass ratio of 1:4, Tween 80 and lipid to the molar ratio of 1:2, and ion strength in a range 20–50 mmol/L. With the optimization operation, the particles of nano-liposomes were below 100 nm and zeta potential was in the range of −10 and −20 mV. The release study of salidroside in vitro from nano-liposomes exhibited a prolonged release profile as studied over a period of 24 h.


Nano-liposome Salidroside Encapsulating efficiency Ethanol injection method In vitro release 



We thank Dr Xu, D and Dr Fu, S. H. of School of Textile and Clothing, Southern Yangtze University, for supplying the Nano-Mastersizer2000 equipments.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Minghui Fan
    • 1
  • Shiying Xu
    • 1
  • Shuqin Xia
    • 1
  • Xiaoming Zhang
    • 1
  1. 1.State Key Laboratory of Food Science and TechnologySouthern Yangtze UniversityWuxiPeople’s Republic of China

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