The high toxicity of endocrine disrupting chemicals (EDCs) has promoted the development of effective techniques for their separation and detection in various types of matrices. In this work, we developed a method for the rapid, reliable determination of 24 EDCs from six different families of organic compounds (viz. alkylphenols, phenylphenols, bisphenol A, parabens, organophosphorus pesticides and triclosan) in cereal-based foodstuffs. The target compounds were subjected to ultrasound-assisted extraction with methanol, cleaned up and preconcentrated by automated solid-phase extraction, and derivatized for their determination by gas chromatography–mass spectrometry (GC–MS). The method features low limits of detection (0.4–23 ng/kg), good precision (3.8–7.2%) and recoveries from 82% to 105%. The proposed method was used to analyse 12 samples of products purchased in Andalusia (Spain). A total of 14 analytes were detected in most of the samples. In any case, their concentrations (3.8–620 ng/kg) were all lower than the applicable maximum residue limits.
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This work was funded by Spain’s Ministry of Economy and Competitiveness (MINECO, Grant CTQ-2015-71321) and partly co-funded by Fondo Europeo de Desarrollo Regional (FEDER).
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Azzouz, A., Colón, L.P., Hejji, L. et al. Determination of alkylphenols, phenylphenols, bisphenol A, parabens, organophosphorus pesticides and triclosan in different cereal-based foodstuffs by gas chromatography–mass spectrometry. Anal Bioanal Chem (2020). https://doi.org/10.1007/s00216-020-02491-1
- Endocrine disrupting chemicals
- Cereal-based foodstuffs
- Ultrasound-assisted extraction
- Automated solid-phase extraction
- Gas chromatography–mass spectrometry