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Long noncoding RNAs: from genomic junk to rising stars in the early detection of cancer

  • Rebeca Miranda-CastroEmail author
  • Noemí de-los-Santos-Álvarez
  • María Jesús Lobo-Castañón
Trends
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Part of the following topical collections:
  1. Young Investigators in (Bio-)Analytical Chemistry

Abstract

Despite having been underappreciated in favor of their protein-coding counterparts for a long time, long noncoding RNAs (lncRNAs) have emerged as functional molecules, which defy the central dogma of molecular biology, with clear implications in cancer. Altered expression levels of some of these large transcripts in human body fluids have been related to different cancer conditions that turns them into potential noninvasive cancer biomarkers. In this review, a brief discussion about the importance and current challenges in the determination of lncRNAs associated to cancer is provided. Different electrochemical nucleic acid-based strategies for lncRNAs detection are critically described. Future perspectives and remaining challenges for the practical implementation of these methodologies in clinical medicine are also discussed.

Keywords

Long noncoding RNA Tumor biomarkers Liquid biopsy Electrochemical biosensors Molecular diagnosis 
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Notes

Funding information

The authors acknowledge the financial support from the Spanish Ministerio de Economía y Competitividad (project no. CTQ2015-63567-R, co-financed by FEDER funds).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Rebeca Miranda-Castro
    • 1
    • 2
    Email author
  • Noemí de-los-Santos-Álvarez
    • 1
    • 2
  • María Jesús Lobo-Castañón
    • 1
    • 2
  1. 1.Dpto. Química Física y AnalíticaUniversidad de OviedoOviedoSpain
  2. 2.Instituto de Investigación Sanitaria del Principado de AsturiasOviedoSpain

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