Tunable superamphiphobic surfaces: a platform for naked-eye ATP detection

  • Fujian Huang
  • Yan Chen
  • Yongqian Wang
  • Fan XiaEmail author
Research Paper
Part of the following topical collections:
  1. Young Investigators in (Bio-)Analytical Chemistry


A superamphiphobic surface composed of two different size ranges of TiO2 nanoparticles was simply fabricated through spraying the perfluorosilane coated TiO2 nanoparticles suspension dispersing in ethanol. The surface chemistry was finely regulated through gradient UV irradiation-induced organic compound degradation to fabricate surface with gradient solid surface energy or wettability. The fabricated surface shows good droplet sorting ability, which can successfully discriminate ethanol droplets with different concentrations. As a proof-of-concept, the biosensor application of this surface was demonstrated by using it for naked-eye ATP detection. Liquid droplets with different concentrations of ATP after ATP-dependent rolling circle amplification (RCA) can be effectively sorted by the surface. This developed biosensor methodology based on droplet sorting ability of the fabricated surface is energy-efficient and economical which is promising for biosensors, point-of-care testing, and biochemical assays.

Graphical abstract


Biosensor Superamphiphobic surface Droplet sorting ATP detection Point-of-care testing 


Funding information

This work is supported by the National Basic Research Program of China (973 Program, 2015CB932600), the National Key R&D Program of China (2017YFA0208000, 2016YFF0100800), the National Natural Science Foundation of China (21525523, 21722507, 21574048, 21874121), The Fok Ying-Tong Education Foundation, China (151011).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

216_2018_1443_MOESM1_ESM.pdf (211 kb)
ESM 1 (PDF 317 kb)
216_2018_1443_MOESM3_ESM.mp4 (12.1 mb)
ESM 3 (MP4 12380 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Fujian Huang
    • 1
  • Yan Chen
    • 1
  • Yongqian Wang
    • 1
  • Fan Xia
    • 1
    • 2
    Email author
  1. 1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanChina
  2. 2.Hubei Key Laboratory of Bioinorganic Chemistry & Materia MedicaHuazhong University of Science and TechnologyWuhanChina

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