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Analytical and Bioanalytical Chemistry

, Volume 411, Issue 1, pp 21–36 | Cite as

Portable glucose meter: trends in techniques and its potential application in analysis

  • Linan Zhang
  • Chunchuan Gu
  • Huan Ma
  • Langlang Zhu
  • Jiajun Wen
  • Hanxiao Xu
  • Hongying LiuEmail author
  • Lihua Li
Review

Abstract

A blood glucose meter is an electronic medical device used for determining the concentration of glucose in blood. These meters have undergone five phases of development: washed blood glucose meters, wiped blood glucose meters, colorimetric blood glucose meters, electrochemical blood glucose meters, and micro, multiple site blood glucose meters. Thanks to their speed, portability, low cost, and easy operation, blood glucose meters have been widely available for use in clinical diagnosis. Recently, coupling of target recognition elements (antibody–antigen recognition, nucleic acid hybridization, enzyme recognition, and click chemistry) with signal transduction and amplification strategies (glucose-generating enzymes, nicotinamide adenine dinucleotide (NADH)-generating enzymes, encapsulated glucose, nanomaterials, and cyclic amplification of DNA) has allowed various targets to be determined via the relationship between the signal of the blood glucose meter and the concentration of targets. In this paper, a brief review of the development and mechanism of blood glucose meters is given first. Then, more details on the application of blood glucose meters in analysis are described, including biomedical analysis, food analysis, and environmental analysis. Finally, the prospect of future development of blood glucose meters is also discussed.

Graphical abstract

Keywords

Blood glucose meter Biomedical analysis Food analysis Environmental analysis 

Notes

Acknowledgements

This study was financed by the NSFC (21405029 and 51173035), Science and Technology Program of Zhejiang Province (LGF18H200005), Young Talent Development Project of Zhejiang Science and Technology Association (2016YCGC007), Medical and Health Technology Development Program of Zhejiang Province (2017KY533), the Social Development Project of Hangzhou (20160533B70).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Linan Zhang
    • 1
  • Chunchuan Gu
    • 2
  • Huan Ma
    • 1
  • Langlang Zhu
    • 1
  • Jiajun Wen
    • 1
  • Hanxiao Xu
    • 1
  • Hongying Liu
    • 1
    Email author
  • Lihua Li
    • 1
  1. 1.Hangzhou Dianzi UniversityZhejiangChina
  2. 2.Department of Clinical LaboratoryHangzhou Cancer Hospital, HangzhouZhejiangChina

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