Analytical and Bioanalytical Chemistry

, Volume 410, Issue 28, pp 7357–7371 | Cite as

Novel mixed hemimicelles based on nonionic surfactant–imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination

  • Wei Liu
  • Ruya Wang
  • Fan Hu
  • Pinping Wu
  • Tao Huang
  • Meriem FizirEmail author
  • Hua HeEmail author
Research Paper


The co-adsorption of mixed nonionic surfactant and imidazolium-based ionic liquid, Triton X100 (TX100), with 1-cetyl-3-methylimidazolium bromide (C16mimBr) adsorbed onto the surface of magnetic halloysite nanotubes (MHNTs) was used as an efficient adsorbent for simultaneous determination of amlodipine and nimodipine in urine. The designed adsorbent was characterized by TEM, TGA, FTIR, and DLS analysis methods. All the parameters that influence the extraction efficiency are optimized with the aid of response surface methodology (RSM). The effects of nonionic surfactant TX100 with different structures of ionic-liquid-coated MHNTs were investigated. Under optimum conditions, extraction recoveries of amlodipine and nimodipine were in the range of 73.8–81.2 and 94.3–96.1%, with RSDs (n = 3) of 2.6–5.5% in spiked urine samples, respectively. The adsorption mechanism principal of mixed hemimicelles was discussed in this study. The limit of detection obtained for analytes was < 0.002 μg·mL−1. To our knowledge, this was the first attempt using a mixed hemimicelle solid-phase extraction (SPE) based on MHNTs and nonionic surfactant and imidazolium-based ionic liquid for the simultaneous determination of amlodipine and nimodipine in biological samples.

Graphical abstract


Mixed hemimicelles Magnetic halloysite nanotube Amlodipine Nimodipine, Triton X100 



This work was financially supported by Independent innovation fund project of agricultural science and technology of Jiangsu Province in 2017 (No. CX(17)1003), Guizhou Provincial Science and Technology Department Joint Fund Project (Qian Kehe LH word [2016] No. 7076), the Project Funded by Research Project of Environment Protection Department of Jiangsu Province (Grant No. 2015026), and Chinese College Students Innovation Project for the R&D of Novel Drugs (No. 201810316242).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Informed consent was obtained for any experimentation with human subjects. All experiments were performed in compliance with the relevant laws and institutional guidelines. Ethical approval for this investigation was obtained from the Research Ethics Committee, China pharmaceutical University School of Medicine.

Supplementary material

216_2018_1348_MOESM1_ESM.pdf (38 kb)
ESM 1 (PDF 37.5 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Analytical Chemistry, School of SciencesChina Pharmaceutical UniversityNanjingChina
  2. 2.Key Laboratory of Biomedical Functional MaterialsChina Pharmaceutical UniversityNanjingChina
  3. 3.Key Laboratory of Drug Quality Control and PharmacovigilanceChina Pharmaceutical University, Ministry of EducationNanjingChina

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