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Analytical and Bioanalytical Chemistry

, Volume 409, Issue 17, pp 4157–4166 | Cite as

Molecularly imprinted polymers based stir bar sorptive extraction for determination of cefaclor and cefalexin in environmental water

  • Jun Peng
  • Donghao Liu
  • Tian Shi
  • Huairu Tian
  • Xuanhong Hui
  • Hua HeEmail author
Research Paper

Abstract

Although stir bar sportive extraction was thought to be a highly efficiency and simple pretreatment approach, its wide application was limited by low selectivity, short service life, and relatively high cost. In order to improve the performance of the stir bar, molecular imprinted polymers and magnetic carbon nanotubes were combined in the present study. In addition, two monomers were utilized to intensify the selectivity of molecularly imprinted polymers. Fourier transform infrared spectroscopy, scanning electron microscopy, and selectivity experiments showed that the molecularly imprinted polymeric stir bar was successfully prepared. Then micro-extraction based on the obtained stir bar was coupled with HPLC for determination of trace cefaclor and cefalexin in environmental water. This approach had the advantages of stir bar sportive extraction, high selectivity of molecular imprinted polymers, and high sorption efficiency of carbon nanotubes. To utilize this pretreatment approach, pH, extraction time, stirring speed, elution solvent, and elution time were optimized. The LOD and LOQ of cefaclor were found to be 3.5 ng · mL–1 and 12.0 ng · mL–1, respectively; the LOD and LOQ of cefalexin were found to be 3.0 ng · mL–1 and 10.0 ng · mL–1, respectively. The recoveries of cefaclor and cefalexin were 86.5 ~ 98.6%. The within-run precision and between-run precision were acceptable (relative standard deviation <7%). Even when utilized in more than 14 cycles, the performance of the stir bar did not decrease dramatically. This demonstrated that the molecularly imprinted polymeric stir bar based micro-extraction was a convenient, efficient, low-cost, and a specific method for enrichment of cefaclor and cefalexin in environmental samples.

Keywords

Molecularly imprinted polymers Magnetic carbon nanotubes Cephalosporins Environmental water Stir bar sorption microextraction 

Notes

Acknowledgments

This work was financially supported by the Chinese College Students Innovation Project for the R&D of Novel Drugs (J1310032), Jiangsu Province Environmental Protection Scientific Research Subject and Science and Technology Project-Nanotechnology Special(ZX201441) of Suzhou Municipal Science and Technology Bureau.

Compliance with Ethical Standards

No conflict of interest exists in the submission of this manuscript, and the manuscript is approved by all authors for publication. The authors have declared no conflict of interest.

Supplementary material

216_2017_365_MOESM1_ESM.pdf (118 kb)
ESM 1 (PDF 118 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Jun Peng
    • 1
    • 3
  • Donghao Liu
    • 1
  • Tian Shi
    • 1
  • Huairu Tian
    • 1
  • Xuanhong Hui
    • 1
  • Hua He
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Analytical ChemistryChina Pharmaceutical UniversityNanjingChina
  2. 2.Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of EducationChina Pharmaceutical UniversityNanjingChina
  3. 3.Key Laboratory of Biomedical Functional MaterialsChina Pharmaceutical UniversityNanjingChina

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