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Analytical and Bioanalytical Chemistry

, Volume 409, Issue 15, pp 3741–3748 | Cite as

Molecularly imprinted polymer prepared with polyhedral oligomeric silsesquioxane through reversible addition–fragmentation chain transfer polymerization

  • Shu-Ping Gao
  • Xue Zhang
  • Li-Shun Zhang
  • Yan-Ping HuangEmail author
  • Zhao-Sheng LiuEmail author
Research Paper

Abstract

Polyhedral oligomeric silsesquioxane (POSS) was utilized to prepare imprinted polymer through reversible addition–fragmentation chain transfer polymerization (RAFT) successfully. The imprinted polymer was made with a mixture of RAFT agent, 4-vinylpyridine (4-VP), POSS monomer [PSS-(1-propylmethacrylate)-heptaisobutyl substituted, MA 0702], and ethylene glycol dimethacrylate (EDMA), with ketoprofen (KET) as template. The influence of polymerization variables, the amount of RAFT agent and POSS monomer, the ratio of KET to 4-VP, and the ratio of 4-VP to EDMA, were investigated on the retention factor and imprinting effect. The greatest imprinting factor of the RAFT agent-based POSS MIP was 15.2, about 1.5 times higher than the RAFT agent-free agent POSS MIP. The permeability, surface morphology, as well as pore size distribution of POSS MIP monoliths made with RAFT agent and without RAFT agent were also studied. The optimal MIP was applied to solid phase extraction for KET from commercial tablets. The mean recoveries of KET for RAFT-based POSS MIP was 85.2% with a relative standard deviation of 2.6%.

Keywords

Molecularly imprinted polymers Polyhedral oligomeric silsesquioxane Reversible addition–fragmentation chain transfer polymerization Molecular recognition Ketoprofen 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (grant no. 21375096) and the National Natural Science Foundation of China (NSFC) on grant 81361140344 (A3 project).

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

Supplementary material

216_2017_315_MOESM1_ESM.pdf (8.4 mb)
ESM 1 (PDF 8632 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Pharmacy, The Second HospitalTianjin Medical UniversityTianjinChina
  2. 2.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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