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Analytical and Bioanalytical Chemistry

, Volume 408, Issue 29, pp 8467–8481 | Cite as

Guilty by dissociation—development of gas chromatography–mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 13 diphenidine-derived new psychoactive substances (NPSs)

  • Pierre M. Geyer
  • Matthew C. Hulme
  • Joseph P. B. Irving
  • Paul D. Thompson
  • Ryan N. Ashton
  • Robert J. Lee
  • Lucy Johnson
  • Jack Marron
  • Craig E. Banks
  • Oliver B. Sutcliffe
Research Paper

Abstract

The prevalence of new psychoactive substances (NPSs) in forensic casework has increased prominently in recent years. This has given rise to significant legal and analytical challenges in the identification of these substances. The requirement for validated, robust and rapid testing methodologies for these compounds is obvious. This study details the analysis of 13 synthesised diphenidine derivatives encountered in casework using presumptive testing, thin layer chromatography and gas chromatography–mass spectrometry (GC-MS). Specifically, the validated GC-MS method provides, for the first time, both a general screening method and quantification of the active components for seized solid samples, both in their pure form and in the presence of common adulterants.

Graphical Abstract

Chemical synthesis and forensic analysis of 13 diphenidine-derived new psychoactive substance(s)

Keywords

New psychoactive substances Characterisation (NMR, FT-IR) Diphenidine Methoxphenidine GC–MS Triage 

Notes

Compliance with ethical standards

This study did not involve research on human participants or animals.

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

216_2016_9969_MOESM1_ESM.pdf (2.1 mb)
ESM 1 (PDF 2147 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Pierre M. Geyer
    • 1
  • Matthew C. Hulme
    • 1
  • Joseph P. B. Irving
    • 1
  • Paul D. Thompson
    • 1
  • Ryan N. Ashton
    • 1
  • Robert J. Lee
    • 1
  • Lucy Johnson
    • 1
  • Jack Marron
    • 1
  • Craig E. Banks
    • 2
  • Oliver B. Sutcliffe
    • 1
  1. 1.Faculty of Science and Engineering, School of Science and the Environment, Division of Chemistry and Environmental ScienceManchester Metropolitan UniversityManchesterUK
  2. 2.Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK

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