Analytical and Bioanalytical Chemistry

, Volume 408, Issue 13, pp 3639–3649

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

  • James J. Bao
  • Feifei Jia
  • Youxin Li
  • Qinggang Liang
  • Yan Wang
Research Paper

Abstract

A novel sulfopropyl ether γ-cyclodextrin polymer (SPE-γ-CDP) through polycondensating sulfated cyclodextrins (SCDs) was synthesized. This synthesis approach also has the potential of preparing other derived cyclodextrins (CDs) polymers. The polymerized SCDs took on both the properties of SCDs and certain characteristics of polymers, such as chiral selectivity and high viscosity. Synthesis parameters, including reactions sequence, sulfation, and polycondensation conditions were investigated systematically. The product was characterized by elemental analysis, infrared spectroscopy (IR), and indirect UV detections prior to use as background electrolytes additive. The separation conditions, including the concentration of SPE-γ-CDP, the concentration and pH of running buffer, separation voltage, as well as the additional organic solution were optimized during chiral separation of neutral, acidic, and basic enantiomers in capillary electrophoresis (CE). SPE-γ-CDP was proven to be an effective chiral resolving agent in CE with the advantages of simple synthesis process, low cost, similar ratio of charge-to-mass, low current, great reproducibility, and reusability.

Graphical Abstract

Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer

Keywords

Sulfopropyl ether γ-cyclodextrin polymer Enantiomer separation Recyclable chiral selectors Great reproducibility Low cost Capillary electrophoresis 

Supplementary material

216_2016_9452_MOESM1_ESM.pdf (489 kb)
ESM 1(PDF 488 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • James J. Bao
    • 1
  • Feifei Jia
    • 1
  • Youxin Li
    • 1
  • Qinggang Liang
    • 1
  • Yan Wang
    • 1
  1. 1.Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and TechnologyTianjin UniversityTianjinChina

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